SurePrint Oligo Pools

RUO

Agilent SurePrint pooled oligo synthesis is an advanced and high throughput production scale parallel DNA synthesis platform. The SurePrint platform has been continuously improved on and optimized over the course of 25 years of innovation and uses state-of-the-art microfluidic DNA writing technology in a process that runs in continuous 24/7 operation for fully custom oligo pools made in rapid turn-around-times.

Every custom oligo pool is synthesized under stringent process monitoring quality control for exceptional uniformity and consistency making them well suited for protein engineering, directed evolution, gene assembly and pooled CRISPR screening.

For Research Use Only. Not for use in diagnostic procedures.

Pooled Oligo Synthesis

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Features

Continuous 24/7 production for custom oligo pools in turn-around times of as few as 3 business days with 90% of orders complete within 6 business days.
Consistent, high complexity, and cost effective parallel synthesis
Superior uniformity with more oligos present in equimolar proportions for fewer false positives or false negatives from over or under-represented sequences
Stringent process monitoring and multi-faceted quality control with parallel control synthesis performed during every production run.
Unlimited applications in protein engineering, directed evolution, synthetic biology, gene assembly, pooled CRISPR screens and single cell profiling.

Featured References

Publications

L. Cao et Al., De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. Science (2020). DOI: 10.1126/science.abd9909 Learn More
Angus M Sidore, Calin Plesa, Joyce A Samson, Nathan B Lubock, Sriram Kosuri, DropSynth 2.0: high-fidelity multiplexed gene synthesis in emulsions, Nucleic Acids Research, Volume 48, Issue 16, 18 September 2020, Page e95, https://doi.org/10.1093/nar/gkaa600 Learn More
Davis et al., Cell Systems 11, 75–85, July 22, 2020
https://doi.org/10.1016/j.cels.2020.05.011 Learn More
Rong, S., Buerer, L., Rhine, C.L. et al. Mutational bias and the protein code shape the evolution of splicing enhancers. Nat Commun 11, 2845 (2020). https://doi.org/10.1038/s41467-020-16673-z Learn More
Rong, S., Buerer, L., Rhine, C.L. et al. Mutational bias and the protein code shape the evolution of splicing enhancers. Nat Commun 11, 2845 (2020). https://doi.org/10.1038/s41467-020-16673-z Learn More
Doni Jayavelu, N., Jajodia, A., Mishra, A. et al. Candidate silencer elements for the human and mouse genomes. Nat Commun 11, 1061 (2020). https://doi.org/10.1038/s41467-020-14853-5
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Nicholas Bogard, Johannes Linder, Alexander B. Rosenberg, Georg Seelig, A Deep Neural Network for Predicting and Engineering Alternative Polyadenylation, Cell, Volume 178, Issue 1, 2019,
Pages 91-106.e23, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2019.04.046. Learn More
Lee HH, Ostrov N, Wong BG, Gold MA, Khalil AS, Church GM. Functional genomics of the rapidly replicating bacterium Vibrio natriegens by CRISPRi. Nat Microbiol. 2019 Jul;4(7):1105-1113. doi: 10.1038/s41564-019-0423-8. Epub 2019 Apr 8. PMID: 30962569.
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John P. Ray, Carl G. de Boer, Charles P. Fulco, Caleb A. Lareau, Masahiro Kanai, Jacob C. Ulirsch, Ryan Tewhey, Leif S. Ludwig, Steven K. Reilly, Drew T. Bergman, Jesse M. Engreitz, Robbyn Issner, Hilary K. Finucane, Eric S. Lander, Aviv Regev &
Nir Hacohen. Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Nature Communications (2020) 11:1237. Epub https://doi.org/10.1038/s41467-020-15022-4 | www.nature.com/naturecommunications
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Ferretti et al., 2020, Immunity 53, 1095–1107. November 17, 2020, Elsevier Inc. https://doi.org/10.1016/j.immuni.2020.10.006 Learn More
Schneider, W.M., Luna, J.M., Hoffmann, H.-H., Sánchez-Rivera, F.J., Leal, A.A., Ashbrook, A.W., Le Pen, J.́r.́m., Ricardo-Lax, I., Michailidis, E., Peace, A., Stenzel, A.F., Lowe, S.W., MacDonald, M.R., Rice, C.M., Poirier, J.T., Genome-scale identification of SARS-CoV-2 and pancoronavirus host factor networks, Cell (2021), doi: https://doi.org/10.1016/j.cell.2020.12.006. Learn More
Hoffmann, H.-H., Sánchez-Rivera, F.J., Schneider, W.M., Luna, J.M., SotoFeliciano, Y.M., Ashbrook, A.W., Le Pen, J., Leal, A.A., Ricardo-Lax, I., Michailidis, E., Hao, Y., Stenzel, A.F., Peace, A., Zuber, J., Allis, C.D., Lowe, S.W., MacDonald, M.R., Poirier, J.T., Rice, C.M., Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors, Cell Host and Microbe (2021), doi: https://doi.org/10.1016/j.chom.2020.12.009. Learn More

SurePrint Oligo Pools

Product Details

Brochure - Selected publications featuring Agilent SurePrint OLS Libraries - 5994-2946EN

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