Autism spectrum disorders (ASD) are a heterogeneous group of behaviorally defined neurodevelopmental disorders characterized by impairments in communication and social interactions along with restrictive and repetitive behaviors. There is increasing recognition that cellular-based abnormalities are associated with ASD including immune and redox dysregulation, oxidative stress and impairments in energy generation. How these systemic abnormalities interact with each other and environmental factors and how these factors interplay to alter behavior remains unclear.
Abnormalities in mitochondrial function are one of the most prevalent metabolic disturbances affecting ASD children. Our research has focused on the etiology of mitochondrial dysfunction in ASD and how mitochondrial abnormalities might interact with other physiological disturbances associated with autism, such as oxidative stress. Our findings indicate that there may be an expanded spectrum of bioenergetic capacity in individuals with ASD such that their mitochondria may adequately generate energy but may be more susceptible to oxidative microenvironments, resulting in a greater susceptibility to disease.
在本次网络研讨会上我们将讨论：
An overview of autism spectrum disorders and associated physiological abnormalities including mitochondrial dysfunction and oxidative stress.
A subset of autism lymphoblastoid cell lines that exhibits atypical mitochondrial responses to oxidative stress.
Whether these atypical mitochondrial responses to oxidative stress can be prevented with targeted treatment.
录制
July 23, 2014
类型
On Demand
语言
英语
仅限研究使用。不可用于诊断目的。
主讲人
Shannon Rose, Ph.D.
Arkansas Children's Hospital Research Institute
