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The purchase price of the Product includes a limited license to use only the amount of the Product delivered herewith on the following terms and conditions.
Definitions“Commercial Purposes” means (a) the practice, performance or provision of any method, process or service, or (b) the manufacture, production, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration of any kind, for the purpose of sale or commercial exploitation, or on any other commercial basis. “Customer” shall include any person or entity which ordered the Product or uses the Product. “Enabled Product” means (a) any product that includes, uses, is developed, identified or made through the use of a Product (including any biological material, cell, organism or animal so derived, developed, identified or made) and (b) any progeny, modifications, improvements or derivatives of any of the foregoing in (a); provided, however, that Enabled Product shall not include any large or small molecule that (i) was identified or discovered through screening using technology covered by the Licensed Patent Rights and (ii) does not otherwise make use of the Licensed Patent Rights. “Licensor Parties” means the President and Fellows of Harvard College, the Massachusetts Institute of Technology and Broad. “Licensed Patent Rights” means (a) any patents and patent applications listed on Appendix A; (b) any substitutions, divisions, continuations, reissues, renewals, re-examinations or extensions of any patents or patent applications of (a), any continuations-in-part of any patents or patent applications of (a) to the extent the claims are directed to subject matter specifically described in a patent or patent application set forth on Appendix A, and any application claiming priority to a provisional application set forth on Appendix A to the extent the claims are directed to subject matter specifically described in a provisional patent application set forth on Appendix A; (c) any letters patents and/or the equivalent issuing therefrom in any jurisdiction based on any of the foregoing; and (d) any foreign or international equivalents of any of the foregoing, including without limitation any applications filed under the Patent Cooperation Treaty. Terms and conditions
Exhibit A
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| Application Number | Title |
| 61/736,527 | Systems Methods and Compositions for Sequence Manipulation |
| 61/748,427 | Systems Methods and Compositions for Sequence Manipulation |
| 61/791,409 | Systems Methods And Compositions for Sequence Manipulation |
| 61/757,972 | Systems Methods And Compositions for Sequence Manipulation |
| 14/105,035 | CRISPR-CAS Component Systems, Methods and Compositions for Sequence Manipulation |
| PCT/US2013/07 4611 | CRISPR-CAS Component Systems, Methods and Compositions for Sequence Manipulation |
| 61/835,931 | Systems Methods and Compositions for Sequence Manipulation |
| 14/183,486 | CRISPR-CAS Component Systems, Methods and Compositions for Sequence Manipulation |
| 61/768,959 | Systems Methods and Compositions for Sequence Manipulation |
| 13812430.0 | CRISPR-CAS Component Systems, Methods and Compositions for Sequence Manipulation |
| 14/497,627 | CRISPR-CAS Component Systems, Methods and Compositions for Sequence Manipulation |
| 14/256,912 | CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS |
| 13824232.6 | CRISPR·CAS Systems and Methods for Altering Expressions of Gene Products |
| 14/183,429 | CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS |
| 61/842,322 | Systems Methods and Compositions for Sequence Manipulation |
| 14/054,414 | CRISPR·CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS |
| PCT/US2013/07 4743 | CRISPR-CAS Systems and Methods For Altering Expressions of Gene Products |
| 14/105,031 | CRISPR-CAS NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION IN EUKARYOTES |
| PCT/US2013/07 4790 |
CRISPR-CAS SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION IN EUKARYOTES |
| 14/183,471 | CRISPR-CAS NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION IN EUKARYOTES |
| 14/259,420 | CRISPR-CAS Component Systems, Methods and Compositions for Sequence Manipulation |
| 14/258,458 | CRISPR-CAS NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION IN EUKARYOTES |
| 61/794,458 | Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof |
| PCT/US2013/05 1418 | Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof |
| 61/835,973 | Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof |
| 61/736,465 | Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof |
| 61/675,778 | Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof |
| 61/721,283 | Inducible DNA Binding Proteins and Genome Perturbation Tools and Applications Thereof |
| 61/836,080 | Methods, Systems and Apparatus for Identifying Target Sequences for CAS Enzymes or CRISPR-CAS Systems for Target Sequences and Conveying Results Thereof |
| 14/104,900 | METHODS, SYSTEMS AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS |
| PCT/US2013/07 4825 | METHODS, SYSTEMS AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS |
| PCT/US2013/07 4812 | METHODS, SYSTEMS AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING |
| 14/183,512 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS, AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS |
| 14/104,837 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS, AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS |
| PCT/US2013/07 4667 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS, AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS |
| 61/915,383 | OPTIMIZED CRISPR·CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 61/836,123 | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Applications |
| 61/847,537 | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Applications |
| 61/871,301 | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Applications |
| 61/862,355 | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Applications |
| PCT/US2014/04 1803 | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Applications |
| 61/806,375 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 61/814,263 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 61/828,130 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 61/769,046 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 61/819,803 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 61/758,468 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 61/802,174 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 14/104,977 | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
| PCT/US2013/07 4691 | ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 14/293,498 | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
| 14/293,674 | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
| 61/836,101 | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
| 14/222,930 | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
| 14/226,274 | ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
| 61/835,936 | Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation |
| 14/105,017 | ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
| PCT/US2013/07 4736 | ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
| 14/104,990 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION |
| PCT/US/2013/07 4819 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 61/836,127 | Engineering of Systems, Methods and Optimized Compositions for Sequence Manipulation |
| 12/290,575 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 13818570.7 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 14170383.5 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 14/213,991 | Recombinant Virus and Preparations Thereof |
| PCT/US2014/03 0394 | Recombinant Virus and Preparations Thereof |
| 61/799,800 | Recombinant Virus and Preparations Thereof |
| 61/862,468 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND OPTIMIZED COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 61/915,407 | DELIVERY, ENGINEERING AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION |
| PCT/US2014/04 1800 | DELIVERY, ENGINEERING AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 61/979,942 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND OPTIMIZED COMPOSITIONS FOR SEQUENCE MANIPULATION |
| 61/995,636 | CRISPR Functional Genomics |
| PCT/US2014/04 1806 | FUNCTIONAL GENOMICS USING CRISPR-Cas systems, COMPOSITIONS, METHODS, screens AND APPLICATIONS THEREOF |
| 61/961,980 | Functional Genomics Using CRISPR-CAS Systems, Compositions, Methods, Screens and Applications thereof |
| 61/960,777 | CRISPR Functional Genomics |
| PCT/US2013/07 4800 | FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, KNOCK OUT LIBRARIES AND APPLICATIONS THEREOF |
| 14/463,253 | FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, KNOCK OUT LIBRARIES AND APPLICATIONS THEREOF |
| 14/481,339 | Delivery, Engineering and Optimizations of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |