Assessing mitochondrial toxicities and liabilities
Identifying compounds that induce toxicities is an important part of lead-optimization during drug discovery. However, most commonly used end‐point assays lack the sensitivity to capture many compounds with mitochondrial toxicity, leading to late‐stage failures.
Agilent cell analysis solutions provide real-time, direct measurements of mitochondrial metabolism with the highest specificity and sensitivity. With these solutions, you can be confident the data you're collecting provides an accurate picture of mitochondrial toxicity risk enabling you to make informed decisions on your drug development pipeline.
No matter your workflow, we have the solution - Don't let mitochondrial toxic compounds slip through!
- Real-time, direct measurements of mitochondrial function
- Highest levels of analytical specificity and sensitivity
- Deeper mechanistic information to rank and characterize drug toxicity
- Workflow options for whole cells, permeabilized cells and isolated mitochondria
See our workflow examples and learn how your industry peers are integrating real‐time, direct measurements of mitochondrial metabolism.
Visit the Agilent Cell Analysis Publications Database or Cell Reference Database to search for publications relevant to your research.
View Agilent Cell Analysis webinars on-demand page to discover applications in toxicology.