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Chemical Development

Chemical Development

Our process solutions are advanced with customer input for any oligonucleotide, at any stage of development, over a wide range of scales from grams to kilograms. Dedicated specialists are assigned to your program; as it advances through the clinic, they are merged with late-stage expertise at the midstage transition to process validation.

Highly robust small-scale lab models enable confident process transfer and process validation at a >500 mmol production scale. Cutting-edge processes at unprecedented scales have been developed for GalNAc phosphoramidite-based RNAi and g-scale GMP production of sgRNA for CRISPR.

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