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Drug Discovery Target Identification and Validation

Expand Your Drug Discovery Pipeline | Target cell metabolism pathways
The critical pathway you may not have considered

The dysregulation of cellular metabolism is frequently observed in disease states, from cancer and diabetes, through to neurodegeneration. Investigating cellular metabolism in your target identification and validation studies therefore delivers an opportunity to expand your drug discovery pipeline, opening new avenues of therapeutic intervention.

Although metabolism seems complex, you don't need to be an expert to generate meaningful insights. Discover the essential metabolic pathways for your drug discovery studies with this interactive metabolic map.

Drug Target
Reference Guide
Image Description

Download our free guide book and start exploring how investigating metabolism can advance your drug discovery studies

Pathways

Disease

Autoimmune disorders, inflammation, allergies, blood born cancers, infection, immunosuppression, tumor microenvironments

Function

Immune cells undergo changes in cellular metabolism to support their function and plasticity. Targeting immune cell metabolism is a promising strategy for selective regulation of immune responses.

Relevant Publication

Fatty acid oxidation
Glycolysis
Electron transport chain

Pathways

Disease

Cancer

Function

Cancer cell metabolism is rewired by genetic mutations to drive tumor growth. Metabolic pathways are therefore promising new targets in the development of cancer therapeutics.

Relevant Publication

Fatty acid oxidation
Glycolysis
Glutaminolysis

Pathways

Disease

Huntington's, Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS)

Function

Mitochondrial dysfunction and oxidative stress are common factors in neurodegenerative disease pathogenesis and premature aging. Modulation of target genes, proteins, and metabolic pathways implicated in these diseases is a promising therapeutic approach.

Relevant Publication

Citric acid cycle
Electron transport chain

Pathways

Disease

Diabetes, obesity, and cardiovascular disease arising from environmental factors

Function

Excess nutrients and stress can cause metabolic imbalances, metabolic reprogramming, and mitochondrial dysfunction. Modulation of receptors or enzymes that restore the balance of nutrient use to 'normal' are promising drug targets.

Relevant Publication

Fatty acid oxidation
Glycolysis
Glycogenolysis
Discover the power of functional metabolic measurements

Find out how you can start incorporating metabolism into your research by reading our Application Brief "Gaining Insights into disease biology for Target Identification and Validation".

In it, you'll discover how Seahorse XF Technology has been used to advance the understanding of potential drug targets in several therapeutic areas.

Agilent metabolic measurement solutions

Enhance your drug discovery workflow with live cell, real‐time metabolic analysis solutions from Agilent. Learn more about our solutions.

Label‐free assay platform for making metabolic measurements in almost any cell type

The Seahorse XFe96 Analyzer and accompanying assays provide drug discovery scientists with well‐established tools for determining metabolic phenotype, detecting glycolytic and mitochondrial inhibitors, and investigating mitochondrial toxicants. Learn more

Flexible microplate reagents for real‐time fluorescence plate reader‐based assays

Easy‐to‐use kits and reagents for measuring real‐time energy flux and mitochondrial function. Convenient for higher throughput assays as they are performed on TRF‐enabled plate readers with 96 and 384 well formats. Learn more

Streamlined sample preparation workflow to deliver actionable results from your live‐cell analysis

The Bravo automated liquid handling platform coupled with Bravo Seahorse Assay Workbench software streamlines your Seahorse XFe96 assay preparation. Generate the results you need while saving labor in the lab, increasing walk‐away time, and achieving consistent data quality. Learn more

For Research Use Only. Not for use in diagnostic procedures.