Drug Discovery Target Identification and Validation
The critical pathway you may not have considered
The dysregulation of cellular metabolism is frequently observed in disease states, from cancer and diabetes, through to neurodegeneration. Investigating cellular metabolism in your target identification and validation studies therefore delivers an opportunity to expand your drug discovery pipeline, opening new avenues of therapeutic intervention.
Although metabolism seems complex, you don't need to be an expert to generate meaningful insights. Discover the essential metabolic pathways for your drug discovery studies with this interactive metabolic map.
Drug Target eBook
Download our new interactive eBook and start exploring how investigating metabolism can advance your drug discovery studies.
Mitochondrial dysfunction and oxidative stress are common factors in neurodegenerative disease pathogenesis and premature aging. Modulation of target genes, proteins, and metabolic pathways implicated in these diseases is a promising therapeutic approach.
Diabetes, obesity, and cardiovascular disease arising from environmental factors
Excess nutrients and stress can cause metabolic imbalances, metabolic reprogramming, and mitochondrial dysfunction. Modulation of receptors or enzymes that restore the balance of nutrient use to 'normal' are promising drug targets.
Label‐free assay platform for making metabolic measurements in almost any cell type
The Seahorse XFe96 Analyzer and accompanying assays provide drug discovery scientists with well‐established tools for determining metabolic phenotype, detecting glycolytic and mitochondrial inhibitors, and investigating mitochondrial toxicants. Learn more
Flexible microplate reagents for real‐time fluorescence plate reader‐based assays
Easy‐to‐use kits and reagents for measuring real‐time energy flux and mitochondrial function. Convenient for higher throughput assays as they are performed on TRF‐enabled plate readers with 96 and 384 well formats. Learn more
Streamlined sample preparation workflow to deliver actionable results from your live‐cell analysis
The Bravo automated liquid handling platform coupled with Bravo Seahorse Assay Workbench software streamlines your Seahorse XFe96 assay preparation. Generate the results you need while saving labor in the lab, increasing walk‐away time, and achieving consistent data quality. Learn more
For Research Use Only. Not for use in diagnostic procedures.