
6200 Series Accurate-Mass Time-of-Flight (TOF) LC/MS
The TOF LC/MS system also supports MS/MS applications by using fragments formed in the desolvation region of the ion source. Using Agilent’s All Ions MS/MS software the TOF system enables compound identification by matching fragmentation patterns with an Agilent MS/MS library. Typical All Ions applications include toxicology analysis with an Agilent Personal Compound Library of 2,500 compounds and veterinary drug analysis using a library of over 600 compounds.
- LC/MS Instruments
Product Details
- Reduce false positives with better than 1 ppm mass accuracy
- Acquire data at 30 spectra per second to ensure excellent data quality for fast UHPLC peaks in high-throughput workflows
- Confidently identify small molecules based on accurate mass and isotopic abundance and chemical composition using Find by Formula in MassHunter software.
- Separate target compounds from interferences with mass resolution of greater than 22,000
- Find impurities at extremely low concentrations – Agilent Jet Stream technology provides low picogram on-column sensitivity
- Identify trace level target compounds – in the presence of more abundant matrix compound – with up to 5 orders of in spectrum dynamic range
- Intuitive “walk-up” software makes the 6230B an ideal analytical tool for medicinal and synthetic chemists as well as biologists.
- New All Ions MS/MS Technique for Targeted and Untargeted Screening on TOF and Q-TOF LC/MS
- Application Notes
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An Application Kit for the Screening of Samples for Analytes of Forensic and Toxicological Interest Using TOF or Q-TOF LC/MS with a Personal Forensics/Toxicology Database
Forensic and Toxicological screening application kit has been developed for use with the Agilent TOF and Q-TOF Mass Spectrometers
- Application Notes
- English
- 05 Mar 2018
- 2.55 MB
Characterization of Glycosylation in the Fc Region of Therapeutic Recombinant Monoclonal Antibody
Fast and efficient LC TOF/MS characterizes intact and digested IgG to identify glycoform masses and profiles. mAb-glyco chip analysis built a glycan accurate mass database.
- Application Notes
- English
- 22 Nov 2017
- 475.16 KB
Peptide Mapping of Glycoprotein Erythropoietin by HILIC LC/MS and RP-LC-MS
A comparison of the separation and sequence coverage of glycoproteins by reversed-phase and HILIC demonstrates the utility of HILIC.
- Application Notes
- English
- 22 Nov 2017
- 407.33 KB
High Resolution Glycopeptide Mapping of EPO Using an Agilent AdvanceBio Peptide Mapping Column
The AdvanceBio Peptide Mapping column gives 100% rhEPO sequence coverage with 45 glycopeptide matches.
- Application Notes
- English
- 22 Nov 2017
- 576.08 KB
Maximizing Metabolite Extraction for Comprehensive Metabolomics Studies of Erythrocytes
This application note describes a method for liquid-liquid extraction of metabolites from erythrocytes.
- Application Notes
- English
- 21 Oct 2016
- 2.51 MB
Metabolomic Profiling of Bacterial Leaf Blight in Rice
This application note describes the use of metabolic profiling via TOF LC/MS and metabolite identification by database searching and Q-TOF LC/MS/MS to investigate the interaction of wild and resistant rice strains with strains of a bacteria that causes bacterial leaf blight in rice.
- Application Notes
- English
- 20 Oct 2016
- 1.92 MB
Qualitative Flux Analysis of a Chondrosarcoma Cell Line Using Agilent VistaFlux
Using Agilent MassHunter VistaFlux for qualitative flux analysis of TCA cycle metabolism in a chondrosarcoma cell line with an isocitrate dehydrogenase 2 mutation.
- Application Notes
- English
- 06 May 2016
- 1.57 MB
Screening and Identification of Emerging Contaminants in Wastewater Treatment Plant Effluents
Screening and Identification of Emerging Contaminants App Note
- Application Notes
- English
- 29 Mar 2016
- 1.24 MB
Analysis of Monoclonal Antibodies
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
- Application Notes
- English
- 03 Feb 2016
- 778.87 KB
Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS
Alabama Department of Forensics demonstrate a sample pre-screening method forensic analyses using the DART-TOF MS with continuous calibration.
- Application Notes
- English
- 27 Aug 2015
- 114.38 KB
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Videos
Agilent Chromatography and Mass Spec Educational Webinar Series
Join Agilent Application Specialists as they present application-specific webinars to help you achieve the best results from your chromatography and mass spec experiments.
Targeted Proteomics: Protein/Peptide Quantitation
On Demand - Discussion includes an introduction to Protein and Peptide Quantitation using normal flow LC/MS and peptide sample prep using Bravo AssayMAP Automation systems.
Opiates, Opioids, and other Drugs – Forensic Analysis in Biofluids
On Demand - Discussion includes how to choose columns, sample prep options, Forensic analysis of biofluids by LC/MS and tricyclic antidepressants in serum by RapidFire MS.

Agilent CrossLab Services
Agilent CrossLab is a comprehensive, coordinated method of providing services, supplies and software that dramatically improves laboratory efficiency and productivity. But even more, Agilent CrossLab is your pipeline to a global team of scientific and technical experts who deliver vital, actionable insights at every level of the lab environment.
Take advantage of Agilent CrossLab services to achieve reliable results and maximum instrument uptime, and ultimately drive improved economic, operational and scientific outcomes.
Agilent CrossLab. From Insight to Outcome
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Software
MassHunter Workstation software – instrument control, data acquisition and processing, reporting
Easy Access software - walk-up software for multi-user environment
Analytical Studio Reviewer software - quick browsing of large batch of data files and easy reporting
Bioconfirm software – protein and peptide molecular weight confirmation and characterization
Mass Profiler Professional software – statistical and differential analysis of multiple sample groups
Mass Profiler software - statistical and differential analysis of up to two sample groups
METLIN Personal Compound Database – database searching for compound identification in metabolomics
LC/MS Series Systems
6100 Series Quadrupole LC/MS Systems
6400 Series Triple Quadrupole LC/MS Systems
6500 Series Accurate-Mass Q-TOF LC/MS Systems
Accessories