Reacts with ZAP-70 expressed in T cells, natural killer cells, pro/pre B cells but not in normal mature B cells. The antibody is a useful aid for classification of a subset of chronic lymphocytic leukemias (CLL). In CLL, ZAP-70 expression is closely associated with an unmutated configuration of the immunoglobulin heavy-chain variable region (IgVH
) genes (1).
* This product is for in vitro diagnostic use only. The product embodies technology described in US Patent 7,329,502 and pending Canadian Patent Application No. 2,413,475.