CD4 is a transmembrane glycoprotein, expressed on normal thymocytes, T-helper cells, majority of mature peripheral T cells, and a subset of suppressor or cytotoxic T cells. CD4 is not found on immature thymocytes. The antibody is a useful aid for classification of anaplastic large cell lymphomas, unspecified peripheral T-cell lymphomas and mycosis fungoides.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
HIER
Clone
4B12
Code Number
M7310
Immunogen
Recombinant protein corresponding to the external domain of the CD4 molecule.
Isotype
IgG1, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
In tonsil, the crowded and isolated T-helper cells show a moderate to strong staining reaction. In liver, the Kupffer and endothelial cells of the sinusoids show a weak to moderate staining reaction.
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.