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CD246, ALK Protein (Autostainer Link 48)

Anaplastic large cell lymphoma (t(2;5) translocation)

CD246, ALK Protein (Autostainer Link 48)

Clone ALK1

Recognizes a formalin-resistant epitope in both the 80 kDa NPM-ALK chimeric and the 200 kDa normal human ALK proteins (1). Normal ALK protein expression is restricted to the central nervous system. The hybrid gene, NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (2). This antibody is a useful aid for classification of anaplastic large cell lymphoma (ALCL).

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