CEA Antibody (Concentrate)

Features

Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years’ experience ensuring quality and innovation in antibodies and reagents

Specifications


Application	Frozen Formalin HIER
Clone	II-7
Code Number	M7072
Immunogen	Purified human CEA from liver metastasis of lung adenocarcinoma (3).
Isotype	IgG1, kappa
Reagent Provided	Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN₃.
Solutions	Concentrate
Species	Mouse Anti-Human
Specificity	In ELISA, the antibody reacts with CEA preparations from both colorectal carcinomas, lung andenocarcinomas and the colon carcinoma cell line LS 174T, whereas the antibody does not cross-react with isolated CEA-related antigens, e.g. NCA-55, NCA-95, NCA-160 and BGP I (4). Based on ELISA, using reduced, carboxymethylated and Smith degraded CEA, the antibody is predicted to react with a conformation dependent epitope, in which the carbohydrate structures of the CEA glycoprotein are involved (4). Using solid-phase competitive immunoassays, monoclonal antibodies to CEA have been classified into five essentially non-interacting epitope groups called GOLD 1-5. Monoclonal antibodies with a high degree of CEA specificity generally belong to epitope groups GOLD 1 or 3. Monoclonal Mouse Anti-Human Carcinoembryonic Antigen (CEA), Clone II-7, belongs to epitope group GOLD 1 (8). See package insert for reference(s).

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Literature

Technical Overviews

Immunohistochemical Staining Methods - Education Guide, Sixth Edition

The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.

Technical Overviews
English
30 Nov 2021
27.05 MB
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Featured References

Product Description References: 1. Nap M, Hammarström ML, Börmer O, Hammarström S, Wagener C, Handt S, et al. Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen. Cancer Res 1992,52:2329-39.
2. Probst-Cousin S, Villagran-Lillo R, Lahl R, Bergmann M, Schmid KW, Gullotta F. Secretory meningioma. Clinical, histologic, and immunohistochemical findings in 31 cases. Cancer 1997,79:2003-15.
3. Uribe M, Fenoglio-Preisler CM, Grimes M, Feind C. Medullary carcinoma of the thyroid gland. Am J Surg Pathol 1985,9:577-94.

Carcinoembryonic Antigen (Concentrate)

Product Details

Immunohistochemical Staining Methods - Education Guide, Sixth Edition

View supported Instructions For Use documents

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