Calcitonin is a 32 amino acid peptide hormone, produced in the parafollicular C cells of the thyroid. Calcitonin acts through its receptors, causing osteoclast-mediated bone resorption and calcium excretion by the kidney. The antibody is useful for the identification of calcitonin-producing C cells and is a useful aid for classification of medullary thyroid carcinoma.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
Polyclonal
Code Number
IR515
Immunogen
Synthetic human calcitonin, aa 1-32, coupled to bovine serum albumin (BSA).
Reagent Provided
Ready-to-use polyclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
Solutions
Autostainer Link 48
Species
Rabbit Anti-Human
Specificity
The antibody reacts with human calcitonin. Traces of contaminating antibodies have been removed by solid-phase absorption with human plasma and bovine serum proteins.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly. No non-specific staining has been observed.