GenetiSure Cyto CGH & CGH+SNP Microarrays

GenetiSure Cyto CGH and CGH+SNP Microarrays are a set of three different microarray designs with content intended for the detection of copy number variations (CNV) only or CNV and copy-neutral loss of heterozygosity (cnLOH) in constitutional DNA samples extracted from blood, saliva, amniotic fluid or CVS.

Intended for use by cytogenetic research and clinical laboratories, this microarray is focused on disease-associated regions linked to developmental delay, intellectual disability, neuropsychiatric disorders, congenital anomalies or dysmorphic features. The 180K CGH array provides high resolution CN down to exon level. The 180K CGH+SNP array provides genome wide CN and high resolution LOH down to 2.5 Mb. And the 8x60K offers a great compromise between coverage, throughput and cost per sample.

For Research Use Only. Not for use in diagnostic procedures.

Human Microarrays

Features

Designed to meet cost, throughput, and resolution needs for any laboratory performing pre or postnatal research
Increased resolution in clinically-relevant target regions sourced from ClinGen, OMIM, and DECIPHER databases, genome-wide backbone with increased resolution in telomeres
Excellent option for both reflex and confirmatory testing in conjunction with other technologies such as next generation sequencing (NGS)
All designs include spike-in probes for sample tracking
Free space on the array allows for easy customization to integrate lab-specific gene/region of interest
180K CGH array design provides exon-level coverage in a selected set of genes
180K CGH+SNP array design includes High-resolution SNP probes, exceeding new ACMG guidelines, for analysis of absence of heterozygosity (AOH) genome-wide in a single experiment
60K CGH array format offers a great compromise between coverage, throughput, and cost per sample
A complete workflow, provided by a single supplier, benefits with inventory control, one-stop service calls and bulk purchasing efficiencies
Probes are annotated against NCBI Build 38 (UCSC GRCh38, Dec. 2013)

Featured References

Publications

Chromosomal microarray analysis of Bulgarian patients with epilepsy and intellectual disability. Peycheva V, Kamenarova K, Ivanova N, Stamatov D, Avdjieva-Tzavella D, Alexandrova I, Zhelyazkova S, Pacheva I, Dimova P, Ivanov I, Litvinenko I, Bozhinova V, Tournev I, Simeonov E, Mitev V, Jordanova A, Kaneva, R. Gene. 2018 Aug 15;667:45-55. doi: 10.1016/j.gene.2018.05.015. Epub 2018 May 9. [Application: Postnatal] Learn More
Pinto D et al. Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants. Nat Biotechnol. 2011 May 8;29(6):512-20. doi: 10.1038/nbt.1852 [Application: General] Learn More
Alesi V et al. Easychip 8x15k: A New Tool for Detecting Chromosome Anomalies in Low Risk Pregnancies, Supporting and Integrating Standard Karyotype J Genet Syndr Gene Ther 7: 277. doi:10.4172/2157-7412.1000277 [Application: Prenatal] Learn More
Chau MHK et al. Characteristics and mode of inheritance of pathogenic copy number variants in prenatal diagnosis. Am J Obstet Gynecol. 2019 Nov;221(5):493.e1-493.e11. doi: 10.1016/j.ajog.2019.06.007. Epub 2019 Jun 14. [Application: Prenatal] Learn More
Ribeiro et al. Upper aerodigestive tract carcinoma: Development of a (epi)genomic predictive model for recurrence and metastasis. Oncol Lett. 2020 May;19(5):3459-3468. doi: 10.3892/ol.2020.11459. Epub 2020 Mar 12 [Application: Cancer] Learn More
Kaur et al. Clinical impact of chromothriptic complex chromosomal rearrangements in newly diagnosed multiple myeloma. Leuk Res. 2019 Jan;76:58-64. doi: 10.1016/j.leukres.2018.12.005 [Application: Cancer] Learn More

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