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Agilent 6545XT AdvanceBio LC/Q-TOF System


Introducing the Agilent 6545XT AdvanceBio LC/Q-TOF system

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Be Agilent sure with our new Biopharma Q-TOF LC/MS

Optimized to be the centerpiece of multiple biopharma workflows, this instrument pushes the performance and reproducibility of protein analysis to new levels, delivering results you can count on, time after time.

Intact protein analysis

Designed for large intact molecule analysis, the 6545XT gives you accurate mass measurements down to low ppm levels. Excellent mass sensitivity without heavy data processing allows you to detect and monitor low-level glycoforms at the intact level. Need to analyze noncovalent protein complexes? The 6545XT has a mass range up to 30,000 m/z, ensuring you get to see your entire charge envelope. Optimizing your system for intact proteins is easy with Swarm autotune.

Peptide mapping

Whether you are performing routine sequence confirmation, or faced with the challenge of hard-to-detect peptides, the 6545XT along with Agilent MassHunter software is ready to help. With MassHunter BioConfirm, you can quickly confirm sequence coverage—automatically—and with MassHunter Walkup, you can give access to anyone in the lab. Useful acquisition tools such as iterative MS/MS help you pull out low-level peptides and improve coverage.

Post-translational modifications

To fully understand the precise composition of your protein, you need to see more than just the backbone structure. You need to know what modifications and variations are occurring during expression. Whether that means characterizing levels of oxidation, localizing deamidation sites, or profiling glycan structures, the 645XT was designed to help. Autotune unlocks the full potential of the system by flexibly optimizing for large proteins or small labile structures such as glycans.


On Demand
From Sample Prep to Processed Results, Characterizing Proteins with LC/Q-TOF
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Download the Agilent 6545XT AdvanceBio LC/Q-TOF system brochure to learn more
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Be Agilent Sure in Biopharma

There has never been a better time to streamline your biopharma workflows, with technology from Agilent. We offer innovative solutions every step of the way.
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For Research Use Only. Not for use in diagnostic procedures.