Be Agilent sure throughout your drug discovery and protein characterization
Optimized to be the centerpiece of multiple biopharma workflows, this instrument pushes the performance and reproducibility of protein analysis to new levels, delivering results you can count on, time after time.
Designed for Biopharma: the Agilent 6545XT AdvanceBio LC/Q-TOF System
Access detailed information at the intact protein level, automatically confirm protein sequence at the peptide level, and understand post-translational modifications—all with this complete workflow solution.
Be confident at the intact protein level with reliable quantitation of major and minor glycoforms and spot-on mass assignments for mAb and subunit analyses. You also get the sensitivity you need to easily detect large, noncovalent complexes under native conditions.
Whether you are performing routine sequence confirmation, or faced with the challenge of hard-to-detect peptides, the 6545XT along with Agilent MassHunter software is ready to help. With MassHunter’s BioConfirm module, you can quickly confirm sequence coverage—automatically—and with MassHunter Walkup, you can give access to anyone in the lab. Useful acquisition tools such as iterative MS/MS and real-time sequence matching can help you pull out low-level peptides and improve coverage for hard-to-detect peptides.
To fully understand the precise composition of your biotherapeutic, you need to see more than just the backbone structure. You need to know what modifications and variations are occurring during expression. Whether that means characterizing levels of oxidation, localizing deamidation sites, or profiling glycan structures, the 6545 was designed to help. Autotune unlocks the full potential of the system by flexibly optimizing for large proteins or small labile structures such as glycans.