Software Status Bulletin

LC/MS Acquisition     LC/MS Acquisition

Preface
-------------------------
This Software Status Bulletin (SSB) documents all known problems in the software
product designated above. The SSB is derived from Known Problem Reports (KPR)
which result from user problems that have been classified as documentation
problems or software defects. When a KPR is written, an identifying number is
assigned to it, and the KPR is added to the next edition of the SSB.

User inputs that have been classified as Enhancement Requests are not documented
in the SSB. User problems that have been submitted, but that have not been
classified by the time the SSB is generated are not included in the SSB.

How to use the SSB
-------------------------
When you experience a problem with a product, first check this SSB to see if the
problem has been reported already, and if there is a temporary workaround
available for the problem, or if the problem has already been fixed by a new
revision. If the problem is not listed in this SSB then you may wish to report
it to the Response Center or to your field support representative.

To determine if your problem is documented in this SSB, first look in the
Keyword Index section of the SSB. Under each keyword is a listing of one-line
descriptions of related KPRs. If any of these sound like yours, locate the KPR
# in the Known Problem Reports section of the SSB, and read the full KPR. The
KPRs in the Known Problem Reports section are sorted by KPR #.

There are two sections in the SSB:
Keyword Index: This index is categorized by keyword. For each KPR there is a
brief description and a KPR #. A KPR may be associated with more than one
keyword.

Known Problem Reports: This section contains KPRs, with all the available
information relevant to the problem. KPRs in this section are sorted by KPR #.

Keyword Glossary

Keyword Index

Keyword: Performance

KPR#:496292 Could not allocate DMA Buffer error on IMQTOF with elevated baseline or complex spectra
KPR#:646558 "Object doesn't support this property or method" Error seen while during initial tune of QTOFs with MassHunter 11

Keyword: User Interface

KPR#:222689 Method MRU grayed out, after optimizer run stopped manually and immediately click on new or open button of acquisition method pane.
KPR#:410995 Discrepancies in decimal values for calibration masses in reference mass list vs tune report list
KPR#:532312 Method MRU grayed out, after optimizer run stopped manually and immediately click on new or open button of acquisition method pane.

Keyword: 

One-line Description:

SampleRunPane throws exception when large numeric value added in data file name with auto Increment enabled

Problem:

The user entered '1234567890123456789012345678901234567890123456789012345678901234567890123123456789012345678901234567.d' as data file name and had selected the Auto Increment check-box.  They then started the run.

This resulted in the following exception 'Value was either too large or too small for an Int32' to be displayed on the screen.  

The user also reported the same exception when the Sample Run pane when the user clicked on 'Run' button.  The run will not start in this case and no indication is given to user.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

MFC column does not work with Qual B.08.00 SP1

Problem:

MFC column does not work with Qual B.08.00 SP1

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Quant error when generating a report with ECM

Problem:

When running Quant in ECM the following error has been reported when generating reports: " Could not find part of the path d:\masshunter\.secure....\codes\resources"

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Antivirus exclusions might be required at customer location

Problem:

On workstations with certain Anti-virus software, the StudyEngine and LogConfigurationEditor's executables may be detected as malware. This mostly happens when Study Engine tries to delete Study cache files from local secure cache or when user tries to clear old log files Log Configuration Editor. 

Temporary Solution:

Allow exceptions for StudyEngine and LogConfigurationEditor's executables in Antivirus Software

Fix Information:

Keyword: 

One-line Description:

MassHunter fails to save the method with the correct instrument setpoints when a  semi-colon is in the Method name

Problem:

Masshunter will not save the method when a semi-colon is contained within the method name. 

Steps To Reproduce: 
 1. Start MassHunter Acquisition software. 
 2. Save a method with name as Acq;Method.m.  The method is saved.
 3. Save As same method with different name as AcqMethod.m.
 4. Reload Acq;Method.m.

The user observes that the QQQ set points are not getting saved for method, which is named with semicolon as one of the character.

NOTE: LC only configuration doesn't have this issue. 

Temporary Solution:

Do not use a semi-colon in the method name. 

Fix Information:

Keyword: 

One-line Description:

Skyline Automation is not reporting sample numbers correctly in status bar.

Problem:

While Skyline is running, the Study manager status bar does not show correct sample numbers. It shows running -1 of 4 sample, for  0 of 4 sample.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

MassHunter Acquisition for LC/MS Crash is Seen After Worklist Completed with ECM 3.5

Problem:

the user started a 12 hour stress test with ECM 3.5.5.  All runs finished and after that MassHunter exception is seen.  After clicking OK, MassHunter Acquisition crashed.  No log book entries are seen.

Temporary Solution:

Investigations show that the defect originates in ECM 3.5.5.  This is not a defect with the MassHunter Acquisition software itself.  As such, there is no workaround is available at this time from MassHunter.

However, the defect has been fixed in ECM 3.6.  Please update to ECM 3.6 if this defect has been observed on the LC/MS system. 

Fix Information:

Keyword: 

One-line Description:

Time and m/z are same in spectrum RTP annotation

Problem:

Time and m/z are same in spectrum RTP annotation

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Running "DA Only" Worklist in ECM mode fails with error "data file ... acquired during locked mode"

Problem:

In ECM mode - all data files are acquired in 'Locked mode' such that they cannot be overwritten.

If a user running in ECM mode wants to run a 'DA Only' reprocessing - Acquisition will throw an error:

"The data file... was acquired during locked mode run and cannot be overwritten. Choose a different data file and restart the sample run."

Temporary Solution:

Instead of running the worklist in DA Only mode from within Acquisition - use the "DA Reprocessor" component installed with Acquisition to perform the same task. 

Fix Information:

Keyword: 

One-line Description:

Tune pane remains enabled, when sample run starts, before ISP shows run state for devices

Problem:

Tune pane remains enabled, when sample run starts, before ISP shows run state for devices

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Multiple messages displayed for Acq console, if restarted during optimizer run 

Problem:

If a restart of Acquisition happens while optimizer is running, duplicate messages are displayed for Optimizer and the online console, on run completion.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Access Denied error followed by Exception seen, on Online Acq console launch

Problem:

Access Denied error followed by Exception seen, on Online Acq console launch

Temporary Solution:

Launch Acquisition console a second time. 

Fix Information:

Keyword: 

One-line Description:

Logbook Viewer Crash

Problem:

Logbook Viewer may crash after changing the purge settings. Will not launch again until restarting PC

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

User Must Enter Numerical Values to Predictable Range or Floating Range Text Boxes in Edit Chromatogram/Signal Plot

Problem:

The Edit Chromatogram / Signal Plots requires that numerical values are the only values that are accepted by predictable range / floating range text boxes. Abundance can only be in numbers.

However, the software allows the user to put in letters or non numerical symbols in these fields. 

Temporary Solution:

Do not put letters or non numerical symbols in these fields. 

Fix Information:

Keyword: 

One-line Description:

 Audit Trail Viewer Crash after leaving Console running for extended period of time

Problem:

 Audit Trail Viewer Crash after leaving Console running for extended period of time

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Method Reports Missing Graph Title

Problem:

When generating a method report for certain QQQ Mixed Mode Method, some graphs do not have titles. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

244207 - Invalid Checksum Error for Study When "Copy methods" Checkbox is Unchecked.

Problem:

Steps to recreate this issue:

The user submits a Worklist Only study in ECM Compliance as follows:
1. On the "Worklist Only" wizard page "Copy methods" checkbox is checked by default.
2. Click "Next" and go to the last page but do not click "Finish".
3. Click "Back" and go back to the first page.  
4. Uncheck "Copy methods" checkbox.
5. Submit and run the study.

The study fails with Invalid checksum error.

Temporary Solution:

There is one workaround available at this time:

Recreate the Study from default with the checkbox not selected.

Fix Information:

Keyword: 

One-line Description:

Changing sampler program and applying or saving method not possible during run.

Problem:

Changing sampler program and applying or saving method not possible during run.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

First Console launch fails after installation.

Problem:

On systems with no “house” Ethernet the LC may not connect the first time, but will on the second try.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

ECM iis worker process recycles after 29 hours and acquisition needs to halt at this time

Problem:

Due to the Windows event log, IIS worker processes are recycled after 29 hours. This is done periodically in automated manner. And since study run was ongoing, it failed with data file upload error.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

"No Injection" sample position gives error on PAL 3 saying "Specified method is not known" and run does not happen

Problem:

"No Injection" as sample position is supported by CTC PAL2 for LCMS MassHunter

Temporary Solution:

Not used in StreamSelect. Workaround is to use Vial with blank run.

Fix Information:

Keyword: 

One-line Description:

Quant does not recompute checksum for a study

Problem:

When Quant processes samples in a study, the data files are modified. The checksum for the data files are re-computed, however the checksum for the stud is not re-computed. The checksum for the study is now no longer valid and editing or re-submitting the study fails in UMAT *user management and audit trail" mode.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Running long worklist causes loss in connection to ECM server 

Problem:

From Acq in compliance mode, a long worklist may result in a loss of network connection to the ECM server. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

User needs to know correct input range for source parameters.

Problem:

Currently the user has no way of knowing what the correct input ranges are for the source parameters in Acquisition.

In Acquisition, enter 600 into the Gas Temp field and click <apply>

You get a message saying the MS QTOF tab has errors but the message does not tell you what the error is and how to correct it.

The message should be more specific and tell you the correct inpur range or there should be a right-click menu that displays the min/max/default values for that field.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Audit trail incorrectly refers to MS2 Scan as "product ion" scan

Problem:

A defect has been observed in the audit trail report generator for Acquisition methods. When a change occurs to a method's scan parameters for scans of type "MS2 Scan" - the audit trail will incorrectly refer to this scan as a "Product Ion" scan. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Acquisition can hang or freeze on load screen if run on unsupported resolutions

Problem:

MassHunter Acquisition has been observed to hang on the splash screen on load if the screen resolution is higher than the supported resolutions for the LCMS QQQ and QTOF bundled monitors:

21.5 inch Monitor: 1920 x 1080 @ 60 Hz
24 Inch Monitor: 1920 x 1200 @60 Hz

Temporary Solution:

If Acquisition hangs at the splash screen - ensure that the monitors resolution is set to one of the supported resolutions listed above. In addition - be sure to set the DPI scaling to 100% in the windows display control panel. Use the keyword "DPI" to find this setting via Windows Search.

Fix Information:

Keyword: 

One-line Description:

Acquisition method audit trail fails to capture changes for "end mass" value of scan type "MS2 Scan"

Problem:

A defect has been observed in the audit trail report generator for Acquisition methods. When a change occurs to the "End Mass" value of the scan type "MS2 Scan" - that change is not captured in the audit trail.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Sample Group Import Mapping Not functional

Problem:

Currently - the sample group column cannot be populated when using an import map via study manager.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Signal plot settings are not saved

Problem:

Help file states that customizations made in signal plot remain after close Acquisition and opening it again. This is not the case.

Temporary Solution:

Customize signa plot each time Acquisition has been closed and launched again.

Fix Information:

Keyword: 

One-line Description:

The Collision Cell Pressure resets to the Default value of 22 psi when System Tune has Both TOF and Quad radio button selected.

Problem:

The Collision Cell Pressure resets to the Default value of 22 psi when
System Tune has Both TOF and Quad radio button selected.

When using System Tune with either TOF or Quad radio button selected the preset collision cell pressure is maintained.  The pressure does not reset to the default  value of 22 psi.

This defect affects System Tune which requires both the TOF and Quad to be tuned.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Sampler Pretreatment displayed in Acquisition Method report when not used

Problem:

This can result in undesired results when recreating methods from a printed Acquisition Method report

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Adding or removing rows to acquisition scan segments table or  can resort the scan segment table and lead to confusion in the method's audit trail

Problem:

In Acquisition's method audit trail - changes to scan segments table can cause the sorting of the table to change in less-than-intuitive ways. This change to the table sort can cause unpredictable - but not incorrect - changes to the method's audit trail.

For example - consider a scan segment table with three rows - all with identical precursor masses. 

If a 4th row is added with a lower precursor mass - it will become first in the new table.

The audit trail will reflect that all 4 scan segments have been changed even though only one row was added to the table. This is because scan segment #1 changed to scan segment #2 once the new row was added (and became the new scan segment #1).

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Iterative MS/MS Does Not Select Ions In Subsequent Injections If the Retention Time Difference Exceeds Threshold

Problem:

If an ion in an Iterative MS/MS run was previously selected, but is found in another injection outside of the retention time threshold, the Decision Engine should choose the ion for an MSMS scan. Currently, the ions that meet these criteria are not selected.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Mass Calibration/Check Tune Report  Displays Low Abundance for mz<600 with Multimode Source

Problem:

Mass Calibration/Check Tune Abundance Values with a Multimode source may report lower than that of a completed System Tune with an AJS Source. This is caused by the source parameters that are applied in each tune; a system tune will optimize source parameters for an AJS source, but the Mass Calibration/Check Tune will use a "Default" set of source parameters to be compatible with multiple sources. As a result, tune ion abundances may be lower when a Mass Calibration/Check Tune is run.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

DA Reprocessor always fails validation of all DA methods

Problem:

A defect has been discovered in the DA Reprocessor version which is included/installed with QTOF Acquisition 10 (for 6456) and 10.1. This defect causes the software to always consider all data analysis only methods to be invalid - with an error "Info.xml is missing".

Temporary Solution:

A workaround is to use the "DA Method Override" column instead of the "Method" column to specify the data analysis method. Any acquisition method can be used in the "Method" column - and it will be ignored because the DA Reprocessor cannot perform acquisition activities. 

Fix Information:

Keyword: 

One-line Description:

2D-LC File Splitter tap appears in method -> DA tab even when no 2D-LC is configured

Problem:

The 2D-LC file splitter tab does not check to determine if a 2D-LC system is configured. As such, the 2D-LC tab will always appear regardless of instrument configuration. If enabled without a 2D-LC system configured, the DA operation will fail with error. 

Temporary Solution:

Do not enable the 2D-LC file splitter if no 2D-LC instrument is configured.

Fix Information:

Keyword: 

One-line Description:

SureMass Conversion failures when data file contains multiple spaces

Problem:

In QTOF Acq 10 and prior, a script was included to automatically convert Profile data into SureMass format as a post-method action. It was observed that if a data file name contained multiple spaces - the conversion would fail. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Hundreds of tiny logbooks uploaded to ECM archived logs location 

Problem:

A user has reported that QQQ Acquisition 10.0 with ECM 3.6 (running in ECM Compliance mode) was uploading many logbooks entries to different log files in the Archive logbook location on the ECM. It was noted that the user had set the Logbook "Purge Settings" value to "1 Day" the shortest possible setting. 

The expected behavior is when the purge settings is set to "1 Day" is that one new logbook is uploaded to the ECM server archive folder only once - and only when launching Acquisition. That logbook will contain log entries that are older than 24 hours. 

Temporary Solution:

It was found that when the user switched to the "1 Week" setting - the upload behavior returned to normal expected behavior. 

Fix Information:

Keyword: 

One-line Description:

NT User Validation Errors seen interrupting running worklists due to response failures from domain controller

Problem:

Users operating MassHunter Acquisition for LC/MS TQ version 10.x and prior in ECM mode have reported incidents where a running worklist would stop with an error "NT User Validation Failed". This error occurs when the ECM server attempts to perform an authentication with a domain controller, and the domain controller does not respond. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

"Project" related errors may occur even though a Project is selected in the Instrument Configuration section of the Control Panel

Problem:

A defect has been discovered in the OpenLab Control Panel where an error is thrown unexpectedly. The error reads "Either there are no projects or you do not have permission for any" and "Project selection is required to launch instrument" even though a valid Project exists and has been selected.

This only occurs after initial installation on a clean system.

Temporary Solution:

As a workaround - simply re-select a project from the project selection menu. If a Project does not exist, create a project and select it. 

Fix Information:

Keyword: 

One-line Description:

Activity Log will not record an error if worklist aborts because the system ran out of storage

Problem:

The activity log stored in Control Panel will not record an entry for the worklist aborting if the abort occurred because the system ran out of available disk space.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Acquisition generates excessive log files when Purge Logbook setting is set to 1 day

Problem:

When the TQ Acq 10 or prior Acquisition logbook purge time is set to 1 day - a defective behavior is observed where many many archived logbooks are being generated into the C:\MassHunter\Log\Acq\Archive directory.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Do not load the default.tun before executing a System Tune on an Ion Mobility QTOF

Problem:

It has been observed that starting a QTOF System Tune after loading the default.tun will fail on IM-QTOF systems. 

Temporary Solution:

It is recommended to execute a QTOF System Tune using any other tune file, if available. 

Fix Information:

Keyword: 

One-line Description:

Error icon appears next to the method path field when setting a DA method in the acquisition method

Problem:

An error icon will appear next to the DA method path after setting a DA method within the Acquisition method's DA parameters. This error flag can be ignored - the applied DA method is correctly linked to the Acquisition method.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Typos found in QTOF tune report

Problem:

Various errors have been found in the QTOF tune report generated by QTOF Acq 10.x and prior. This includes the word "Pressures" instead of "Pressure" and other minor typos. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Error seen when opening the "worklist run parameters"

Problem:

A rarely reproducible error message has been observed when opening the "Worklist Run Parameters" dialog in Acquisition. The error prevents the dialog from opening. Clicking "OK" will close the error.

Temporary Solution:

The error does not interrupt operations. You can close Acquisition and reopen to try opening the dialog again. 

Fix Information:

Keyword: 

One-line Description:

Content imported into OpenLab Server / ECM XT can take 2 minutes before appearing in data analysis applications

Problem:

When using the import tools to upload new data/content into the OpenLab Server / ECM XT environment - multiple databases have to be updated before that content is visible to the MassHunter applications. This process can take up to 2 minutes after the file has been completely uploaded. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Methods can be edited during acquisition and applied to the instrument in Workstation mode

Problem:

While a method run is in progress - it is possible to change the running method and apply that to the instrument. Those changes will take effect immediately. However - this is not possible in Networked Workstation configuration. In Networked Workstation a running method cannot be edited.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

PC MS/MS Decision Engine will continue acquiring MS(1) spectra for a period after the start of a new time segment

Problem:

Users have reported that the "Advanced" decision engine - enabled by the checkbox labeled: "Use PC MS/MS Decision" will acquire multiple MS(1) spectra rather than correctly collecting MS/MS spectra at the start of a new time segment. 

Temporary Solution:

It is recommended to disable use of the PC MS/MS Decision engine. 

Fix Information:

Keyword: 

One-line Description:

Secure Project Directory is not supported with MassHunter Acquisition

Problem:

OpenLab Control Panel has an option to "secure project folder" which will set Windows NTFS permissions on the project path. Enabling this feature will break MassHunter acquisition in a variety of ways. Errors can be seen indicating that the "system cannot find the file specified" and/or "Failed to start MassHunter acquisition engine processes".

Temporary Solution:

Disabling the "secure project folder" and creating a new project will restore normal functionality. 

Fix Information:

Keyword: 

One-line Description:

Maximum limit of 1024 targets per time segment for all QTOF instruments using the classic decision engine

Problem:

There is a technical maximum for the number of target ions for MS/MS acquisition for all QTOF instruments using the "Classic Decision Engine". That limit is 1024 targets per time segment. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

MassHunter 11 (Acq, Quant, or BioConfirm) cannot co-reside with any other OLSS installing application

Problem:

MassHunter 11 (including Acquisition for TOF/QTOF, Quantitative Analysis, and BioConfirm) cannot co-reside on a client PC with any other application which installs OpenLab Shared Services (this includes ChemStation C.01.x.,  CDS 2.x, or EZChrom of any version).

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

PC restart is required following installation of MassHunter before reinstalling the software

Problem:

When uninstalling MassHunter Acq 11, the uninstalling application does not check to see if the acquisition engines have been completely shutdown before removing the applications from disk. Further - during reinstallation MassHunter Acquisition does not check to see if the Acquisition engines are already running.

As a consequence - the installation following an uninstallation may fail with error.

Temporary Solution:

The fix is to simply restart the computer following uninstallation. This will remove all remaining services and allow the reinstallation to complete successfully. Please note - at the last step of the uninstallation, the user is asked if they want to restart the computer, this is checked by default.

Fix Information:

Keyword: 

One-line Description:

Error message - Current operation cannot be performed on multiple columns - unexpectedly seen in Worklist table

Problem:

An error has be seen when performing a fill down operation on the data file column which reads "Current operation cannot be performed on multiple columns" even when only one column is selected.

Temporary Solution:

Simply click into any single cell of the worklist then attempt the fill down operation again. 

Fix Information:

Keyword: 

One-line Description:

SPT Report Reports Failures with Windows 10 LTSC (Long-Term Servicing Channel)

Problem:

The system prep tool does not properly detect the version strings associated with Windows 10 Enterprise edition (LTSC) and will report "FAIL" in the final report. This can be ignored. Windows 10 Enterprise edition (LTSC) (Version 1809) is fully supported with MassHunter 11. 

Temporary Solution:

This SPT failure can be ignored.

Fix Information:

Keyword: 

One-line Description:

Content imported into OpenLab Server / ECM XT can take 2 minutes before appearing in data analysis applications

Problem:

When using the import tools to upload new data/content into the OpenLab Server / ECM XT environment - multiple databases have to be updated before that content is visible to the MassHunter applications. This process can take up to 2 minutes after the file has been completely uploaded. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

"An Error occured" message appears when configuring an instrument in OLCP

Problem:

A defect has been discovered in the MassHunter Acquisition 11 implementation of the OpenLab control panel which occurs when the "Configure Instrument" window is open for more than ~5 minutes. When the user clicks "OK" to confirm and apply the instrument configuration (IP addresses) - a popup message appears saying "Error, An error occurred" with no further information. Clicking the "Close" button to dismiss the error causes an identical error message to occur again. This process repeats approximately 10-15 times.

Temporary Solution:

As a workaround - simply click "Close" to dismiss the error message until the message no longer appears. This will take approximately 10-15 clicks to completely dismiss the message. Once completed - the system will indicate that the instruments were configured successfully and you can proceed to launch the instrument.  

Fix Information:

Keyword: 

One-line Description:

User must re-link imported DA methods after acquisition methods are imported into a new project location

Problem:

When importing a method which has a linked Da method, and that DA method is imported from one project to other project in the same compliance mode (workstation to workstation / networked workstation to networked workstation),aAn error is shown while saving\running that , "Da method path doesn't belong to the current project path. parametre name:StoragPath"

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

QTOF Run State does not reflect idle status - shows "pre run" instead

Problem:

It has been observed that the QTOF Run state displayed in the instrument actuals displays "Prerun" instead of "Idle" when the MS is in it's Idle status.  

Temporary Solution:

This status issue has no impact on instrument behavior. It can be ignored.

Fix Information:

Keyword: 

One-line Description:

Don't use the Advanced Decision Engine with Targeted MS/MS

Problem:

Users have reported that the "Advanced" decision engine - enabled by the checkbox labeled: "Use PC MS/MS Decision" will crash throwing errors like "PLX/PCI transceiver not responding" and/or "PCA: internal error [25]" when the Acquisition rate is high.

Temporary Solution:

Disable the "advanced decision engine" by unchecking "Use PC MS/MS decision" in the method.

Fix Information:

Keyword: 

One-line Description:

Spectra graphics missing from tune report

Problem:

It has been observed that in some cases, the spectra graphics generated during a tune may not be included in the resulting tune report even though the tune completes successfully. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Older LC modules (G1315A, for example) may take a long time to update instrument status

Problem:

It has been observed that some older LC modules (like the G1315A, released circa 1996) may take a long while before updating their instrument status as shown in the instrument diagram in MassHunter.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Acquisition will no longer prompt to save layout when switching layouts, contexts, or closing the application

Problem:

A major user frustration has been the incessant prompts to save the application layout whenever switching between different layouts, contexts (tune/acquisition) or closing the application. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Data files acquired in extended mass range show incorrect maximum drift times (all 6560 IMQTOFs)

Problem:

When acquiring data in extended mass range (20k) mode, the maximum drift time recorded in the data file is different from what is set under the maximum drift time method parameter. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

TOF High voltage electronics enabled at vacuum level 3E-6, instead of 2E-7.

Problem:

It has been observed that the time-of-flight high voltage electronics are being enabled at a vacuum level of 3E-6 instead of the expected 2E-7. This does not present a risk to the safety of the instrument operators nor a risk to the instrument itself, and can be ignored.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Importing older worklists may fail with error: unable to get UniqueNaming Node from worklist template

Problem:

The error: "unable to get UniqueNaming Node from worklist template" might be seen when importing wkl worklist files generated by older versions of LCMS QTOF acquisition (B.07 or prior). 

Temporary Solution:

As a workaround - this worklists can be loaded in QTOF Acq 10.1/10.0 - saved with a new name - then imported by QTOF Acq 11. 

Fix Information:

Keyword: 

One-line Description:

Default reference mass calibration is loaded each time the MassHunter engines are restarted

Problem:

When a user either: Shutdown the QTOF WorkStation PC or Close down MH Software and and click "Close Connection" to shutdown MH engine. Relaunch MH, Turn on Calibrant, the Mass Accuracy of Calibrant ions are observed to be shifted compared with last time before the shutdown. 

Temporary Solution:

To work around this problem, user must load back a good tunefile in tune view before making an injection in Acquisition view every time the user shutdown his/her workstation PC

Fix Information:

Keyword: 

One-line Description:

"Use PC for MSMS decisions" is defaulted "ON" when running in AutoMSMS or TargetedMSMS modes

Problem:

It has been decided to deprecate the "Use PC for MSMS decisions" feature in QTOF Acq 11 update 1. The option will still be available, but it will no longer be enabled by default on new methods.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Method report for Ultivo should be generated to A2 paper

Problem:

The Ultivo acquisition method report has too many columns to fit into a single row of an A4 or 8.5" x 11" paper. The recommendation would be to generate the report to an A2 PDF so that everything can be displayed as a single row.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

MMI Source Mass Calibration / Check picks ion 118 instead of 121 in TOF tune calibrant - prevents successful calibration

Problem:

A defect has been discovered in the MMI calibration routine on TOF/QTOF instruments where the tune algorithm tries to find mass 118 instead of mass 121 during the final stages of the Mass Calibration / Check.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

With MassHunter Study Manager - additional login entries will appear in the activity log without an application name

Problem:

In Study Manager - whenever a user logs in through the OpenLab Shared Services login dialog, a separate login entry is added to the activity log by the OpenLab Shared Services platform without specifying the application in which that login screen was displayed - as a result, it is difficult to determine which application the user logged into. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

DA Reprocessor does not launch if instrument is not configured

Problem:

The DA Reprocessor does not launch if an instrument is not configured. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Default ChipCube Vcap is too high when instrument is put into standby

Problem:

When put into standby, the ChipCube default Vcap is set to 4000V. While the impact of this setting has been low, the default Vcap standby voltage will now be 1000V to improve the safety margin. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

New Firmware update utility available which allows for updates using SCP (secure copy protocol) over SSH instead of FTP

Problem:

With recent changes to Microsoft Defender default firewall policies - an increase in reports of failed firmware updates have been received. To improve the robustness of the firmware update process - we have released a new firmware update utility to deliver the same firmware via SSH instead of FTP. These update utilities are available on SubscribeNet with the label "SSH" contained in the title.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

20,000 scan range not available in QTOF mode - only IMQTOF mode

Problem:

In QTOF Acq 11 - the UI allows the user to define a method where the mass scan range of the instrument can be set to Max = 20,000 m/z. However - this extended mass range is only available with certain IMQTOF instruments with updated logic firmware and only when running in IMQTOF mode. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Analytical Column Setup button causes error on first click

Problem:

An error is observed when clicking on the "Analytical Column Setup" on a new install for the first time. Clicking "Ok" to dismiss the error - then clicking the button again will no longer lead to an error.

Temporary Solution:

Just click "OK" and ignore the error. It'll work the second time.

Fix Information:

Keyword: 

One-line Description:

AP-MALDI source not recognized when attached

Problem:

A defect has been discovered in QTOF Acq 11.0 where the iButton associated with the AP-MALDI source is not recognized in the software. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Audit Trail defect causes method changes which were already "applied" to the LC to not be written to the method audit trail when the method is saved

Problem:

A defect has been discovered in the QTOF Acq 11.0 audit trail. This defect causes changes to the LC method (MS method parameters are not impacted) to NOT be captured in the method audit trail when the method is saved. The missing audit trail items occur when changes to the method are "applied" to the instrument (by clicking the "apply" checkbox icon next to the method selection dropdown menu) before the method is saved. 

If the "Apply" checkbox is not selected before the method is saved - then ALL changes are properly captured in the method audit trail when the method is saved.  

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

"Skipping overlapped injection" is logged as a warning to the system logbook

Problem:

In Acquisition 10.2 and prior, the message "Skipping Overlapped Injection because high throughput optimization is not enabled in sampler method" was logged as a warning. This is defective behavior - this is a method parameter, a setting choice shouldn't be logged as a warning.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Worklist cannot be loaded because data file path is not within project folder

Problem:

In MassHunter 11 - if a worklist throws the error "xxxx.d is outside the storage path D:\Projects\..." this indicates that the worklist contains references to paths which exist outside of the project path. This prevents the worklist from being opened - even to correct the path problem. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

HPLC-ChipCube is not recognized as a valid source for the QTOF instrument tune

Problem:

A defect has been discovered in QTOF Acq 11.0 which causes tunes to fail with error "ForTOFMassCalibration: Error unknown source type" - when the ChipCube source is installed.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Configuring a 2D-LC Cluster causes the "add/modify/delete" columns dialog to not display anything under available columns

Problem:

A defect has been discovered in the "Add/Modify/Delete Column" settings with QTOF Acq 11.0 when configured with a 2D-LC cluster. Once the 2D-LC cluster is configured, the "available columns" pane to appear empty - preventing the user from adding columns to the worklist table. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Auto-Reference Valve is causing the Humidity Valve supplying nitrogen to the QTOF electronics is being closed incorrectly

Problem:

A defect has been discovered in the implementation of the Auto-Reference Valve control which causes the Humidity Valve supplying Nitrogen to the electronics on TOF/QTOF instruments to close prematurely.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Including a space character in data file path (including project name) breaks 2D-LC file splitter

Problem:

A defect has been discovered in the 2D-LC File splitter workflow where including a space character anywhere in the data file path will cause the Post-acquisition 2D-LC File splitter activity to crash with error:

Splitter: DA operation failed.

Temporary Solution:

Check that no space character exists anywhere in the data file path (particularly in the project name). If necessary, create a new project and copy methods/worklists/data files from the old project to the new project.

Fix Information:

Keyword: 

One-line Description:

Delete study permission governed by the person who launches study manager - not the user interacting with study manager

Problem:

In the TQ Acq 10.1 implementation of study manager - the "delete" study permission is only available to the Acq_Manager. The idea being that the user who can delete a pending study should be limited to the Acquisition manager. 

However - the check for this permission occurs against the user who launches Study Manager in the first place - not the user who is actively operating Study Manager.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

QRAI Workflows in Quant not automatically creating Qualifiers or properly labelling QRAI band information in chromatogram labels

Problem:

A defect was discovered in QTOF Acq 11.0 which causes Quant to fail to generate qualifier ions when running the "New Method from Library - LC" workflow with QRAI data. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Locked applications do not appear blurred when Windows OS thumbnail is enabled

Problem:

The Windows operating system's Taskbar Thumbnail feature allows a user to see the current state of any running application by hovering over the icon in the task bar. 

This preview defeats the blurring visual effect which MassHunter applies to locked application to obfuscate what could be sensitive data. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Issues with using keyboard shortcuts when filling out the sample position column in the worklist

Problem:

Users have noted that when using the "tab" key to navigate into the Sample Position field in the worklist - the first character typed into that field is not included in the entered text. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Switching worklists from dropdown in worklist table causes Activity Log to capture the wrong worklist name

Problem:

Simply loading one worklist, followed by another worklist - then running the second worklist causes the system logbook to report that you just ran the first worklist. 

For example - I created two worklists - 1Row.wkl containing 1 sample, and a 2Row.wkl with two samples.

I loaded 2Row.wkl (did not run it) then loaded 1Row.wkl then ran it.

The activity log reported that I ran 2Row.wkl

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Publish Format selection in Acq Method -> DA -> Quant -> tab is non-functional 

Problem:

In the MassHunter Acquisition method, under the DA section -> Quant - there exists a "Publish Format" selection which - in theory - allows the user to choose what final output is generated by the Quant reporting engine (PDF, CSV, etc). With Quant 11.1, this feature broke and will not be fixed. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Acquisition's lock screen remains on top above all other apps

Problem:

When the Acquisition lock screen is active - it is configured to sit on-top of all other applications, even when Acquisition is minimized. 

Temporary Solution:

Move the lock screen to the corner of you screen so as to avoid it.

Fix Information:

Keyword: 

One-line Description:

At symbol "@" appears in various actuals fields due to a localization issue in SFC driver

Problem:

A defect in the SFC driver causes the "at" symbol '@' to appear in multiple instrument parameters. This is caused by a fault in the localization of the strings associated with these SFC actuals - but it does not impact the accuracy of those values.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Loading invalid method in Acquisition yields unhelpful tooltip in worklist

Problem:

When you select a method in the Acquisition worklist - it checks to see if the appropriate info.xml is contained in that method. If it is missing - perhaps because the method is not an acquisition method but rather some other type of method (like a Quant reporting method) - the tooltip will simply read - "info.xml file does not exist in Acquisition method path". While this is not a particularly helpful message - it is accurate. 

Temporary Solution:

Make sure to select an appropriate Acquisition method in the acquisition worklist. 

Fix Information:

Keyword: 

One-line Description:

After deleting user defined column, worklist editing throws exception

Problem:

When deleting / removing user defined columns from the worklist table - further editing of the rows of that worklist may trigger a crash in the worklist table.

The crash will include the error message: "xxxxx is neither a DataColumn nor a DataRelation for table WorklistRow."

Here's an example workflow which will cause the crash: 

Create worklist with 3-4 samples
Add 3-4 user defined columns
Save worklist
Delete 2-3 user defined columns
Immediately click inside any cell of worklist

Temporary Solution:

The current workaround is to relaunch the UI where error is seen (e.g. Console \ Offline Worklist Editor \ DA Reprocessor), create a new worklist from default and do not add the columns intended to be deleted.

Fix Information:

Keyword: 

One-line Description:

Including a "." period character in a portion of the data file path causes the file to get stuck in the File Upload Queue - Networked Workstation

Problem:

A defect was found in the validation of data file paths which failed to ensure that no "." period characters are included in the data file path of any datafile in the worklist. Periods are illegal characters in ECM XT - so any file with a period in its path would get stuck in the File Upload Queue and have to be manually removed.

Temporary Solution:

Do not include "." period characters in your data file paths.

Fix Information:

Keyword: 

One-line Description:

Quad tune report may state failed even though all tests passed.

Problem:

Quad tune report may state failed even though all tests passed. If Overall Quad tune report states failed examine all sections. If there are no failures listed but overall result is failed, then there is no fault with the instrument. The issue is with the report. 

Temporary Solution:

If all sections of tune report state passed but overall result states failed, then re-run the quad tune.

Fix Information:

Keyword: 

One-line Description:

Migration of .wkl worklists created in 10.x causes scripts to change position within the worklist

Problem:

A defect has been found in TQ Acq 12.0 which causes worklists created in 10.x which contain a script to change the position of the script in the worklist. Specifically - the script is seen jumping from the end of the worklist to the beginning. 

Temporary Solution:

Edit the worklist after it is imported to have script entries ordered correctly.

Fix Information:

Keyword: 

One-line Description:

Failed to retrieve permission 'Add script' for logged-in user

Problem:

In some circumstances, when a user opens the "Worklist run parameters" pane, an error message is encountered. The error reads: "Failed to retrieve permission 'add script' for logged-in user {username}".

This error should only be observed once.

Temporary Solution:

Close MassHunter Acquisition and click "close connection" in the OpenLab Control Panel. Reopen MassHunter and the error should not reoccur.

Fix Information:

Keyword: 

One-line Description:

Setting "Always use Default project" causes Acquisition to launch into the wrong project

Problem:

Have a system where you've previously opened Acquisition into a Project. I'll call it "Alpha".

In the OpenLab Control Panel - with all MH processes shutdown - create a new Project - I'll call it "Gamma".

In the instrument's view, edit an instrument and select the "Gamma" project in the "Default Project" field. Tick the setting "Always use Default Project."

Note that the Project field will now show "Gamma" as the selected project. 

Launch the instrument and observe that Acquisition launched into the "Alpha" project.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Hard to find 54-vial plate in "add multiple samples" workflow in Offline Worklist Editor

Problem:

Users have reported that it is too difficult to find the 54-vial plate option in the "add multiple samples" plate options in TQ Acq 12.0. 

Temporary Solution:

The plate is present - it's just in the PAL3 sampler section. 

Fix Information:

Keyword: 

One-line Description:

PAL 3 plate numbering in the "add multiple samples" dialog doesn't directly map to PAL3 method editor

Problem:

The plate numbering in the "Add multiple samples" dialog may not map to the same numbering used in the installed plates configured in the PAL 3 driver.  

Temporary Solution:

Once the samples are added to the worklist - correct the plate numbers in the worklist table manually. 

Fix Information:

Keyword: 

One-line Description:

Samples acquired out of order after "insert" and "Delete" edits to the worklist

Problem:

A user has reported that their TQ Acq 12 worklist was acquired out of order - and at no point did they use the "randomize" order functionality new to TQ 12. 

This occurred when one inserted and deleted rows from the worklist while not saving the worklist between those actions.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

File Splitter requires a 1D detector to work

Problem:

If a 2D-LC setup is used in which no 1D detector is configured, then the file splitter cannot work.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Changing the number of rows enabled during study submission leads to undesired outcomes in Study Manager

Problem:

During the worklist review stage of Study submission (in Study Manager) - changing the number of rows enabled causes two undesired outcomes:

1- the sample count shown in the pending studies tab is incorrect. It has not been updated for the change.

2- the activity log will record errors indicating: "could not find Worklist row for given Worklist row ID {GUID} 

Temporary Solution:

Simply ignore these undesired outcomes. 

Fix Information:

Keyword: 

One-line Description:

"View Data" button does not work if Project has space in the name

Problem:

In TQ Acq 12 and 12.1 - the "View Data" button should open a data file into Qual for review. However - if there is a space in the project path, this will fail with error.

Temporary Solution:

Open the data file in Qual directly - rather than using the "View Data" shortcut.

Fix Information:

Keyword: 

One-line Description:

Data fie Path length validation added in TQ Acq 12.0 and QTOF Acq 11.0 overly limiting

Problem:

In QTOF Acq 11 and TQ Acq 12.0 - a check was added to the worklist table which would prevent users from running samples if the path length specified for the data file name was too long. This was added to prevent a failure case which would occur when the path length specified by the user exceeded limits of the operating system. However - this limitation was found to be overly constraining and prevented previously working data file naming schemes used by customers. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Acquisition console crashes when using Japanese IME in Worklist Run Parameters Window

Problem:

A defect has been discovered in the Worklist Run Parameters that causes the Acquisition application to crash (close) without error when using the Japanese IME (Input Method Editor) in some situations. 

Temporary Solution:

As a workaround: Confirm the selected translation candidate by Enter key with each character input. Then input another Japanese word. 

Alternatively: Use the previous version of the Microsoft Japanese IME. 
1. Search "IME' on search box and select "日本語 IME 設定" (Japanese IME settings)
2. Click on "全般" (General)
3. Scroll down to the bottom in the 全般 window and switch from オフ(Off) to オン(On) for "以前のバージョンの Microsoft IME を使う" (Use Previous version Microsoft IME) under "互換性" (Compatibility)

Fix Information:

Keyword: 

One-line Description:

"Add multiple samples" dialog throws validation errors when sample name field contains colons and forward-backward slashes

Problem:

Colons and forward and backward slashes are valid characters for the sample name field. However, due to a defect in the "Add multiple samples" dialog, the software would throw a validation error if the sample name field contained either of these characters. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Data modified field not changing when modifying method in Acquisition

Problem:

A defect has been found in the File -> Open (method, worklist, etc) dialogues where the "Date Modified" column was not updating or reflecting changes made within the method. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Worklist run failed to start from first row in randomized worklist

Problem:

A defect has been found in the worklist table impacting worklists that have been extensively edited after being randomized. The defect causes acquisition to start from a random row of the worklist instead of the first row.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Worklist error occurs in DA reprocessor if Sample Audit trail is displayed for any data file in the DA Reprocessor worklist

Problem:

When a data file's sample audit trail is opened in an Audit Trail viewer- the sample audit trail cannot be modified by any other application. When running with the DA Reprocessor - the sample audit trail is updated. If the sample's audit trail is open in any other application (including the audit trail viewer in Acquisition) - the DA Reprocessor will fail when attempting to reprocess the sample in question. 

The error message seen may vary but one common error is: "Storage object is already disposed". 

Temporary Solution:

Close the audit trail for the sample and re-run the DA reprocessor.

Fix Information:

Keyword: 

One-line Description:

Instrument configuration report is not updated except by running instrument configuration in OpenLab Control Panel

Problem:

A user who updates the MS firmware may notice that the instrument configuration report does not reflect the updated firmware immediately. Instead - the Instrument Configuration must be updated through the Instrument Configuration option in the OpenLab Control Panel. Once updated via the Control Panel - the instrument configuration report will reflect the latest firmware version.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

 Tune file name referenced in Tune Report (included in .d data file) does not match the .tun file name as shown in Qual Sample Information

Problem:

A discrepancy has been discovered between the .tun file referenced in the .d\AcqData\TuneReportNegative.pdf (or TuneReportPositive.pdf) and the .tun file indicated in the Qual -> Sample Information pane for the same data file.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Worklists samples acquired out of order - not randomized

Problem:

A defect has been found in the worklist table where samples are not acquired in the displayed order. This issue is more frequent in worklists that have undergone extensive editing, such as adding, appending, inserting, randomizing, deleting, and reordering samples.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Performing a tune in only one polarity will cuase tune report to be missing collision cell parameters

Problem:

Performing a system tune or transmission tune in a single polarity (positive or negative) instead of both polarities (positive and negative) will cause the tune report to omit the section on collision cell parameters. 

Temporary Solution:

Perform tunes in both polarities. 

Fix Information:

Keyword: 

One-line Description:

Acquisition method editor unloads method after sample run - leads users to think they cannot edit an existing method

Problem:

A defect was introduced in TQ Acq 12.0 and QTOF Acq 11.0 where the Acquisition method is unloaded from the method editor such that the software is no longer "editing" the method expected by the user. The method parameters are displayed - and changes can be made - but when the user clicks "Save" the software treats the save as a "Save as" action because it believes a new method is being created. If the user then selects the existing method on disk they believed they were editing - the software throws an error that a method cannot be overwritten. 

Temporary Solution:

One can simply re-load the method before making further edits. 

Fix Information:

Keyword: 

One-line Description:

"Index was outside the bounds of the array" error occurs when deleting rows of a randomized worklist

Problem:

It has been found that when deleting rows of a randomized worklist - the error "Index was outside the bounds of the array" may occur. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Unable to change default instrument configuration settings like pump pressure units

Problem:

A defect has been found in the Acquisition instrument configuration where settings changed from default by the user would be ignored by Acquistion on instrument launch. For example, if the user were to set the pump pressure unit from "Bar" to "PSI" - the UI would accept the setting change, but it would be ignored once acquisition launched - "Bar" would still be displayed. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Saving new worklist with full data file paths in data file name column causes the paths to disappear

Problem:

A defect was introduced in TQ Acq 12.1 which causes worklists that have a full data path defined in the "Data File" column to be replaced with just the data file name upon save.

Temporary Solution:

This issue does not occur if the worklist is saved FIRST before adding the data file paths. 

Fix Information:

Keyword: 

One-line Description:

Overlapped injection with wellplate autosamplers causes sample to be aspired twice, wasting sample volume

Problem:

A defect has been found in MassHunter Acq for LC/MS QTOF 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Scheduled tunes will not occur until Worklist Completion popup is acknowledged

Problem:

A defect was found in the scheduled tune functionality whereby scheduled tunes would not proceed unless and until the "Worklist Completed" popup was acknowledged and closed. This popup is displayed whenever a worklist is completed successfully. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

ResponseCheck sample type incorrectly removed from Acquisition Worklist sample type column

Problem:

The ResponseCheck sample type was incorrectly removed from TQ Acq 12.0 and 12.1 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Inserting a sample into the worklist table puts the new row into an unexpected location

Problem:

A defect has been identified in the worklist table. When inserting new rows (via right-click and selecting “insert sample”), the sample is placed in an unexpected row, either above or below the intended row.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Audit trail of method in Study reflects study version instead of source Acquisition method

Problem:

When creating a study where the methods used for that study are copied into the study container, the audit trail for those methods will indicate that they were copied from a method whose version does not exist. In fact, they are using the version of the study itself, rather than the source method. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Crash seen when launching Acquisition into project which had been duplicated in the Control Panel and then edited

Problem:

A defect was found in MassHunter Acquisition which caused the application to crash when launching into a project which had been duplicated from another project and then edited. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Changes to source method settings for tune relative to default methods leads to 2 minutes of added not-ready time

Problem:

QTOF Acq 12.1 changed the default method's source conditions (temperatures) to improve instrument performance of any new method. When exiting the tune state, the instrument takes approximately 2 minutes longer than QTOF Acq 11 and prior to become ready given the updated source conditions. This change is expected. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

In order to have "injection volume" "As Method" via CSV import, either leave entire column empty or use "-1" to indicate "as method"

Problem:

In order to get "as method" populated into the worklist table during a CSV -> Worklist import - use the token "-1" instead of the text "As method". 

Acquisition is expecting a numerical value for Inj Vol, and using "As method" as a text string will result in an error during import. 

Temporary Solution:

Use "-1" to signify "as method" for the injection volume column of an imported CSV sample list.

Fix Information:

Keyword: 

One-line Description:

User Defined Columns display name changed from previous "User Defined" to "Numeric" and "Text"

Problem:

A defect was introduced in QTOF Acq 11 and TQ Acq 12.0, causing the “User Defined” columns in the Add/Modify/Delete Columns dialog to be incorrectly renamed as “Numeric” and “Text” instead of “User Defined” and “User Defined X” (where X is an integer between 1 and 10). These columns must be named “User Defined” to ensure their contents map correctly into the Data Analysis applications.

Temporary Solution:

The user can simply edit the Display Name to ensure the column is properly labeled as "User Defined" and not "Numeric" or "Text". 

Fix Information:

Keyword: 

One-line Description:

Unable to import CSV with Sample Amount and Total Sample Amount populated

Problem:

A defect has been found which prevents the "Sample Amount" and "Total Sample Amount" values from properly being imported from a CSV or XLS into the Worklist table.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Error method on LC stack can cause a method change that does not get captured in the method's audit trail

Problem:

In the normal course - all changes to a method are documented in the method's audit trail. However - a defect has been uncovered which can lead to method changes which are not reflected in the method's audit trail. This occurs if a method is loaded on the instrument independently from Acquisition - for example if an error method is set on the LC stack. An error method is a method which is stored on the LC modules and is automatically loaded and applied whenever the instrument enters into an error state (leak detected, for example). When this occurs - the MassHunter method editor will immediately update to reflect the method changes that were applied to the LC stack. If the user then makes any changes in the Acquisition method, and then saves that method, only the changes that occurred by the user's direct action will be reflected in the audit trail. The changes which occurred because the LC stack loaded its error method will not be reflected in the method's audit trail. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

SureMass conversion will fail with down-sampled 10 to 4 GHz data.

Problem:

SureMass data processing is not supported with 10 GHz data that has been down-sampled to 4 GHz data for use in BioConfirm's Maximum Entropy deconvolution (MaxEnt). If you plan to use 10 GHz data in Quant with SureMass - do not down-sample the 10 GHz data.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Intelligent Reflex method fields show method validation errors (red boxes) drawn around Quant methods after closing connection in Networked Workstation configuration

Problem:

In QTOF Acquisition 12.0 and later, as well as TQ Acquisition 12.0 and later, when operating in the Networked Workstation configuration, closing the instrument connection (including during a PC reboot) may cause the Acquisition method to show red validation errors around the Quant methods used in the Intelligent Reflex workflow upon relaunch.

Temporary Solution:

This issue does not affect worklist acquisition. You can continue to run or start your worklist using the existing methods, and everything will function correctly. If you wish to resolve the issue in the method editor, simply reselect the Quant methods in the browse dialogs.

Fix Information:

Keyword: 

One-line Description:

Worklist validation does not allow dilution factor values greater than 99,999.99

Problem:

A worklist validation check added in TQ Acq 12.1 and 12.2 prevents users from using dilution factors greater than 99,999.99. 

Temporary Solution:

The dilution factor can be corrected once the data is loaded in Quant. Quant supports dilution factors as large as 1E305. 

Fix Information:

Keyword: 

One-line Description:

Not possible to review audit trail of Worklist Template 

Problem:

A defect has been identified which prevents "reviewing" the audit trail of a Worklist Template. An error is thrown, "The audit trail for {WorklistTemplate} cannot be reviewed as it is either use or it needs to be reloaded to display newer entries. Reload the audit trail to continue with review."

Temporary Solution:

A suggested workaround is to remove any worklist templates that should not be used for routine operation out from the Project via Content Management. In this manner - routine operators will only be able to use templates that remain in the project structure.

Fix Information:

Keyword: 

One-line Description:

Red validation box does not get cleared when root data folder path is corrected

Problem:

In the worklist run parameters dialog, if the "root data folder" path is invalid - correcting the path by selecting the "..." browse button and picking a valid path does not immediately clear the red validation warning. 

Temporary Solution:

Simply click the "OK" at the bottom of the Worklist Run Parameters window will close the window if the path is valid - even if the red validation box is not cleared. 

Fix Information:

Keyword: 

One-line Description:

Revident Only - "No Injection data" files have "No Data points" for the first few spectra acquired after a "No Injection" blank

Problem:

The Revident QTOF automatically switches polarity to the opposite polarity of the previously run sample in order to dissipate any charge accumulation on the ion optics. For any injected sample, the flip occurs before data is written to disk. But for no-injection blanks, the flip occurs after data is written to disk. As a result - if a "no-injection" blank follows another sample (either vial-injected or no-injection) the first few spectra recorded to disk will show "NO DATA POINTS" for the sample's main polarity when viewed in Qual or in the real-time TIC display.

This issue impacts only "No Injection" samples. Samples injected from any vial or wellplate position will not be impacted by this issue. 

If IRM reference mass correction is enabled - this may cause the reference-mass indicators to indicate that reference masses were missing for one or more spectra of the run. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Audit trail for new method will show "Signal processing changed from High Resolution to Dynamic Range"

Problem:

When creating a new method, the new methods' audit trail will show an entry with description, "Signal Processing changed from Hign [sic] Resolution to Dynamic Range". This entry is recorded regardless of changes the user makes to the method. 

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

Defect in LC driver / firmware causes method migration error - "CRC does not match the previously given solvent parameters"

Problem:

A defect has been found in the LC Driver and LC firmware which causes an error when loading a some methods. Impacted methods are those that were created on an LC instrument with a different solvent definition than those on the LC instrument loading the method. 

When the driver and firmware migrate the solvent definitions, it will append the text "(Migrated)" to the solvent name in the method UI. 

This added (Migrated) text causes an error on the LC firmware which is then presented to the user with the error message: "CRC does not match the previously given solvent parameters". 

Temporary Solution:

To resolve the issue - simply ignore the error message and then modify the LC method to select a solvent without the "(Migrated)" text. Finally, save and then reload the saved method. One should not see any further error after loading the updated method.

Fix Information:

Keyword: 

One-line Description:

Object reference not set to an instance of an object error when loading 6575 methods on 6546 instrument

Problem:

A defect exists where loading methods that were built on a 6575 instrument onto a 6546 instrument causes a crash with error message when subsequent methods are loaded. The error message reads: "Failed to load method. Object reference not set to an instance of an object." It appears this error condition occurs only on systems running non-English configurations. 

Temporary Solution:

If you access "configure tune" and select and tune the Active Instrument Mode set in the Acquisition method beforehand, this error does not occur.

Fix Information:

Keyword: 

One-line Description:

Scripts to run Mass calibration prior to worklist or method does not function

Problem:

The default script to run Mass calibration automatically before a worklist or method execution is not functioning properly. 

Temporary Solution:

As a workaround, manually trigger mass calibration before running a method or worklist.

Fix Information:

Keyword: 

One-line Description:

Offline method editor incorrectly saves methods using "QTOF System Tune" instrument mode

Problem:

A defect has been found in the offline method editor where the "Instrument Mode" saved by the offline editor is always the default "QTOF System Tune". When this method is loaded in online acquisition - if the "Active Instrument Mode" does not match - it will require the method to be re-saved before it can be run. 

Temporary Solution:

If your Active Instrument Mode is not the default "QTOF System Tune" - and you want to use a method saved by the Offline Method editor - you will need to load the method in Acquisition proper (one connected to the instrument), click "yes" to have the method updated to reflect the Active Instrument Mode, and simply save the method. It will then be ready for use.

Fix Information:

Keyword: 

One-line Description:

InstrumentStandby Script fails to turn TQ into standby mode

Problem:

A defect has been found in the InstrumentStandby script included with TQ Acq 12.2 and prior where the TQ is found to be pulled out of standby mode immediately after the script executes. This was caused by a timing flaw.

Temporary Solution:

n/a

Fix Information:

Keyword: 

One-line Description:

In DA Reprocessor, worklist containing intelligent reflex injctions may display injection volume "as method" while regular samples show actual injected volume

Problem:

In the DA Re-processor, when loading completed worklists - the "Injection Volume" shown should display the injection volume that was actually injected when the worklist was executed. In "As Method" cases, the actual injection volume information is found by looking up the content of the .d data file stored on the local file system or in Content Management (ECM XT). If the data file is missing, or otherwise cannot be found, the worklist will display "As Method" rather than the actual injection volume. 

A defect has been found in the look-up process for data files associated with injections automatically added by the Intelligent Reflex feature. The issue is caused by defective handling of the data file path string such that this look-up fails to find such samples. In these cases, the worklist table will simply display what was stored in the worklist itself - in this case, "As Method".

Temporary Solution:

As a workaround - the actual injection volumes injected for intelligent reflex samples can always be found by examining the individual data files in the various MassHunter data analysis applications. In MassHunter Qual, for example, you can view the actual injection volume in the Sample Information pane or in any printed report which includes the Injection volume parameter. In MassHunter Quant, the injection volume is a column that can be added in the Sample table. Similarly Quant includes the injection volume in many of the shipping Quant report templates. All of these will include the correct, actual injection volume for all samples.

Fix Information:

Keyword: 

One-line Description:

Not able to configure a single acquisition method to perform BOTH Iterative MS/MS and Blank Carryover - Second Pass quant method cannot be set

Problem:

A defect has been identified in the method validation logic when configuring an Acquisition method to run both Blank Carryover intelligent reflex and Iterative MS/MS simultaneously. When these workflows are enabled together, the system expects the "2nd Pass Quant Method" field to be set. However, the browser field is disabled, preventing selection of a method and ultimately blocking the method from being saved.

Temporary Solution:

There are two workarounds:

1.) Instead of using a single acquisition method to perform Iterative MS/MS AND the blank carryover workflow - set two separate methods. For example, use the "Save As" function to save the iterative MS/MS method as another name, then configure each method to perform ONLY Iterative MS/MS or Blank Carryover, not both. 

2.) Alternatively, to continue using a single Acquisition method, set the "Blank Carryover" workflow to "As Worklist". Then, define the blank carry over details in the worklist table itself, rather than as part of the Acquisition method. 

Fix Information:

Keyword: 

One-line Description:

WalkUp 4.2 does not stay in the foreground with QTOF Acquisition 11

Problem:

While running samples with WalkUp 4.2 and QTOF Acquisition 11 - the Acquisition UI will continually jump in front of the WalkUp console whenever a sample run is completed. 

Temporary Solution:

As a workaround, you can enable "Secure Mode" or "Hide Data System" in the WalkUp administration console. 

Fix Information:

Keyword: Performance

One-line Description:

Could not allocate DMA Buffer error on IMQTOF with elevated baseline or complex spectra

Problem:

Failures have been observed on IMQTOF's acquiring spectra containing elevated baselines or particularly complex profiles. The failure typically seen will include the error "Could not allocate DMA Buffer". 

Temporary Solution:

n/a

Fix Information:

Keyword: Performance

One-line Description:

"Object doesn't support this property or method" Error seen while during initial tune of QTOFs with MassHunter 11

Problem:

A defect has been observed while attempting to run an Initial Tune with MassHunter 11 after default tune files had been deleted from the smartcard. 

The error thrown was "Object doesn't support this property or method". 

Temporary Solution:

n/a

Fix Information:

Keyword: User Interface

One-line Description:

Method MRU grayed out, after optimizer run stopped manually and immediately click on new or open button of acquisition method pane.

Problem:

Method MRU grayed out, after optimizer run stopped manually and immediately click on new or open button of acquisition method pane.

Temporary Solution:

n/a

Fix Information:

Keyword: User Interface

One-line Description:

Discrepancies in decimal values for calibration masses in reference mass list vs tune report list 

Problem:

The exact masses enumerated in the reference mass list is different from the tune masses reported in the tune reports. 

Temporary Solution:

n/a

Fix Information:

Keyword: User Interface

One-line Description:

Method MRU grayed out, after optimizer run stopped manually and immediately click on new or open button of acquisition method pane.

Problem:

Method MRU grayed out, after optimizer run stopped manually and immediately click on new or open button of acquisition method pane.

Temporary Solution:

n/a

Fix Information: