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ABSTRACT |
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In this webinar, Dr. Chris Denning discusses short stories around his research, particularly around the use of Cas9/CRISPR to modify the genome of hiPSC-CMs, along with applications of Agilent Seahorse XF and CardioECR to understand more about disease and variation in the human population. Cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) provide a powerful tool for modelling impact of disease and drugs on structure and function. The presentation will also provide early data on the use of Cas9/CRISPR reporter lines to conduct large scale screens of compounds that may be useful in inducing cardiomyocyte maturation. |
WHAT YOU WILL LEARN |
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- Cas9/CRISPR is an effective approach to induce polymorphic changes in the stem cell genome,
- Cardiomyocytes from human pluripotent stem cells can phenocopy disease states effectively, providing new routes for mechanistic understanding and drug evaluation for cardiovascular disease, as well as
- Applications of Agilent’s Seahorse XF Analyzer and CardioECR technologies to understand more about modelling and characterizing cardiovascular disease.
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DATE |
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Tuesday, September 24, 2019 |
TIME |
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08:00 PDT (Los Angeles)
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11:00 EDT (New York)
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16:00 BST (London)
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Register for the webinar now >> |
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For Research Use Only. Not for use in diagnostic procedures.
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PRESENTED BY |
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Chris Denning
Professor, and Head of Department for Stem Cell Biology
Director of the Centre for Biomolecular Sciences University of Nottingham
United Kingdom |
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