Agilent Technologies introduces an atmospheric pressure MALDI source for proteomics
PALO ALTO, Calif., June 3, 2002
Agilent Technologies Inc. (NYSE: A) today introduced an atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) source for use on the Agilent 1100 Series LC/MSD Trap SL ion trap mass spectrometer. Co-developed by MassTech, Inc. of Burtonsville, Maryland, U.S.A. and Agilent, the AP-MALDI source provides gentle ionization that is particularly well suited to the analysis of peptides and related compounds of interest to scientists doing proteomics research.
Ideal for Fast Screening
Because the AP-MALDI source operates at atmospheric pressure, a sample plate can be loaded in seconds -- simplifying operation and greatly increasing sample throughput. This makes an LC/MSD Trap SL equipped with the AP-MALDI source ideal for fast screening of samples derived from proteins. The 96-well sample plates are compatible with sample deposition by robotic preparation systems, which can also increase throughput.
An Agilent 1100 Series LC/MSD Trap SL equipped with the AP-MALDI source has shown excellent sensitivity for subfemtomole sample amounts spotted onto the sample plate. AP-MALDI analysis consumes only a fraction of the total sample deposited, so sample plates can be stored for further analysis.
Searchable MS/MS Spectra
Agilent's AP-MALDI system quickly and easily generates searchable MS and MS/MS spectra from protein digests. Heated drying gas directed onto the sample plate helps reduce the formation of matrix clusters, resulting in cleaner mass spectra. The specificity of MS/MS data reduces the need for high coverage and yields more conclusive database matches.
The AP-MALDI source uses Agilent's standard ion source mounting system. It takes only minutes to switch between AP-MALDI and the ESI, APCI, and APPI sources already available for the LC/MSD Trap. For the proteomics researcher, this mean that AP-MALDI can be used for fast initial screening and the system quickly converted to electrospray ionization for in depth LC/MS/MS analysis of samples of interest.
U.S. Pricing and Availability
The price of the G1990A Atmospheric Pressure MALDI source will be approximately $65,000. Shipments are expected to start in early fall, 2002.
Information about Agilent's life science products and services is available at www.agilent.com/chem.
About MassTech Inc.
MassTech Inc. is a privately owned start-up company incorporated in 2001 for developing AP-MALDI and infrared MALDI-related products. Information about the company is available on the web site www.apmaldi.com.
About Agilent Technologies
Agilent Technologies Inc. (NYSE: A) is a global technology leader in communications, electronics and life sciences. The company's 37,000 employees serve customers in more than 120 countries. Agilent had net revenue of $8.4 billion in fiscal year 2001. Information about Agilent is available on the Web at www.agilent.com.
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