Agilent Technologies and Caliper Technologies add cell assay capability to the Agilent 2100 Bioanalyzer

PALO ALTO and MOUNTAIN VIEW, Calif., Oct. 1, 2001


Agilent Technologies Inc. (NYSE: A) and Caliper Technologies Corp. (NASDAQ: CALP) today introduced the Agilent 2100 Bioanalyzer Cell Assay Extension and a Cell Fluorescence LabChip kit for the Agilent 2100 Bioanalyzer. Jointly developed by Agilent and Caliper Technologies, the new products enable biochemists, molecular-, protein- and cell-biologists to perform cell assays, thereby making the 2100 bioanalyzer the industry's only platform able to analyze RNA, DNA, proteins and now cells.

Customers using the cell assay extension and the Cell Fluorescence LabChip kit will benefit from the ease of use of the personal system and the low cell consumption. Applying lab-on-a-chip technology, it is possible to automate the analysis of six samples, each including up to 25,000 cells.

The Agilent 2100 Bioanalyzer Cell Assay Extension

Together with the newest version of the Agilent 2100 Bioanalyzer the cell assay extension provides additional capability for pressure-driven sample movement in addition to the existing electrokinetic liquid movement and electrophoretic separation capabilities.

The new capability also further extends the application portfolio of the bioanalyzer from molecular separation assays to simple flow cytometric analysis, for a broad range of cell parameters and a variety of cell samples. Analysis of endogenous fluorophores like green fluorescent protein (GFP), extra- and intracellular-antibody staining as well as apoptosis detection by Annexin-V binding are the first applications. Further applications are expected to be developed in the future.

Cell Fluorescence LabChip Kit

Cell assay applications such as fluorescently labeled Annexin-V for apoptosis detection, as well as monitoring of transfection efficiency by antibody staining or GFP detection, are now possible in addition to the existing electrophoresis-based separations. The new Cell Fluorescence LabChip kit provides special chips and reagents that allow analysis of up to six pre-stained cell samples per chip.

The Agilent 2100 Bioanalyzer is one of the only commercial systems that allow analysis on one microfluidic platform of important biomolecules such as DNA, RNA and proteins as well as that of whole cells. With lab space being scarce in many companies, Agilent and Caliper are responding to a critical customer need by exploiting the flexibility that can only be achieved by lab-on-a-chip technology.

U.S. Pricing and Availability

The Agilent 2100 Bioanalyzer Cell Assay Extension is available for order now and is priced at $11,300. The Cell Fluorescence LabChip kit is available now and is priced at $515. The price for the newest bioanalyzer version remains the same. Shipments of all cell assay products for the Agilent 2100 Bioanalyzer are expected to begin in late October.

About Caliper Technologies

Caliper Technologies Corp. is a leader in lab-on-a-chip technology. Caliper designs, manufactures, and commercializes LabChip devices and systems that enable experiments that ordinarily require laboratories full of equipment and people to be conducted on a chip small enough to fit in the palm of a child's hand. The chip contains a network of microscopic channels through which fluids and chemicals are moved in order to perform the experiment. The LabChip system is designed to streamline and accelerate laboratory experimentation and has potential applicability in a broad range of industries including pharmaceuticals, agriculture, chemicals and diagnostics. Caliper has established multiple strategic and commercial alliances and has built a leading intellectual property estate in microfluidic technology.


About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is a global technology leader in communications, electronics and life sciences. The company's 43,000 employees serve customers in more than 120 countries. Agilent had net revenue of $9.4 billion in fiscal year 2000, as restated to reflect the sale of its healthcare business. Information about Agilent is available on the Web at www.agilent.com.

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The new Agilent 2100 Bioanalyzer Cell Assay Extension together with the Agilent 2100 Bioanalyzer is now able to perform simple flow cytometric analysis.

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Caliper®, LabChip®, and the LabChip logo are U.S. registered trademarks of Caliper Technologies Corp.

Contact:

Miriam Schroeder, Agilent
Agilent Technologies
+49 7243 602 259
miriam_schroeder@agilent.com

Doug Forsyth, Agilent
+1 650 485 5603
doug_forsyth@agilent.com