Agilent broadens its Cell analysis portfolio

Agilent broadens its cell analysis portfolio

Agilent is helping researchers answer some of the most ground-breaking biological questions - all with cellular metabolism. Cellular metabolism is the set of chemical reactions that take place within a cell. These reactions sustain life, allowing cells to grow, divide and respond to their environment, making metabolism a central aspect of biology.

Altered or abnormal metabolism is observed in a wide range of diseases, from cancer and diabetes to neurodegenerative disorders. In cancer, for example, metabolism is altered to fuel the cells’ rapid growth and division, resulting in the cells becoming dependent on sugar [1]. Studying metabolism is key to understanding these diseases and could lead to the development of future therapies.

An innovative approach to investigating metabolism

Researchers investigating metabolism traditionally measured enzyme activities, protein levels, and the concentration of metabolic substrates such as glucose and lactose. But these techniques provided a static view of metabolism, which is actually a dynamic and rapidly changing cellular process.

Agilent Seahorse XF technology was a leap in the evolution of cellular metabolism analysis. For the first time, this technology allowed researchers to investigate metabolism in live cells, as it happened – capturing the true dynamic changes in their cell’s functions and phenotypes.

An expanded portfolio

Now, Agilent has broadened its portfolio of cell analysis solutions through the acquisition of Luxcel Biosciences. The new additions, MitoXpress and pH-Xtra Glycolysis assays, use soluble sensors to analyze metabolism, making them ideal for high throughput applications. These assays perfectly complement Agilent’s Seahorse XF technology, providing researchers with more options to analyze metabolism.

With Agilent’s expanded range of cell analysis solutions, researchers can easily select the optimum instrument and assay for their biological question, workflow and throughput needs. So more researchers can answer even more questions about cellular metabolism, leading to better understanding of diseases and the discovery of potential therapeutics

For Research Use Only. Not for use in diagnostic procedures

References

(1) Hanahan, D. and Robert A. Weinberg, Hallmarks of Cancer: The Next Generation. Cell, 2011. 144(5): p. 646-674.


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Agilent in Cell Metabolism

Agilent cell analysis technology provides a new window into cell metabolism

Mitochondrial function and glycolysis play critical roles in a variety of cellular processes, including cellular activation, proliferation, differentiation, cell death, and disease progression. Agilent Cell Analysis technology enables the measurement of several metabolic parameters and functions using live cells, in real time, enabling researchers to assess energy expenditure, substrate utilization, mitochondrial function, and general cellular homeostasis. Agilent Cell Analysis technology is used with many different cell lines, including primary cells, adherent and suspension cell lines, isolated mitochondria, and islets, 3D cultures, Zebrafish embryos, C. elegans, D. melanogaster, yeast, and other biological materials; and across a number of research areas including cancer, obesity, diabetes, metabolic disorders, immunology, cardiovascular, neurobiology, virology, aging, and more.

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