All publications by Title

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

K. Makowski, J. F. Mir, P. Mera, X. Ariza, G. Asins, F. G. Hegardt, L. Herrero, J. Garcia and D. Serra
Eur J Med Chem; 2017 May 5. 131. 207-221

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

K. Makowski, J. F. Mir, P. Mera, X. Ariza, G. Asins, F. G. Hegardt, L. Herrero, J. Garcia and D. Serra
Eur J Med Chem; 2017 May 5. (131). 207-221

10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species

den Hartigh L J, Han C Y, Wang S, Omer M and Chait A
J Lipid Res; 2013 Nov 1. 54(11). 2964-78

11beta-HSD1 reduces metabolic efficacy and adiponectin synthesis in hypertrophic adipocytes

Koh E H, Kim A R, Kim H, Kim J H, Park H S, Ko M S, Kim M O, Kim H J, Kim B J, Yoo H J, Kim S J, Oh J S, Woo C Y, Jang J E, Leem J, Cho M H and Lee K U
J Endocrinol. 2015 Apr 15(3). 147-158 [Epub ahead of print].

14-3-3zeta regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

S. M. Schoenwaelder, R. Darbousset, S. L. Cranmer, H. S. Ramshaw, S. L. Orive, S. Sturgeon, Y. Yuan, Y. Yao, J. R. Krycer, J. Woodcock, J. Maclean, S. Pitson, Z. Zheng, D. C. Henstridge, D. van der Wal, E. E. Gardiner, M. C. Berndt, R. K. Andrews, D. E. James, A. F. Lopez and S. P. Jackson
Nat Commun; 2016 Sep 27. 7(12862)

18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes

J. S. Kirkwood, C. L. Miranda, G. Bobe, C. S. Maier and J. F. Stevens
PLoS One. 2016 Jun 8(6). e0157118 [Epub ahead of print].

2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells

S. Y. Wang, Y. H. Wei, D. B. Shieh, L. L. Lin, S. P. Cheng, P. W. Wang and J. H. Chuang
PLoS One. 2015 Jul 3(7). e0130959 [Epub ahead of print].

2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

Yao J, Chen S, Mao Z, Cadenas E and Brinton R D
PLoS One; 2011 Jul 1. 6(7). e21788

2016: A ‘Mitochondria’ Odyssey

C. Cherry, B. Thompson, N. Saptarshi, J. Wu and J. Hoh
Trends in Molecular Medicine; 2016 Apr 14.

3-Hydroxybutyrate Regulates Energy Metabolism and Induces BDNF Expression in Cerebral Cortical Neurons

K. Marosi, S. W. Kim, K. Moehl, M. Scheibye-Knudsen, A. Cheng, R. Cutler, S. Camandola and M. P. Mattson
J Neurochem. 2016 Oct 14 [Epub ahead of print].

3-Iodothyronamine decreases expression of genes involved in iodide metabolism in mouse thyroids and inhibits iodide uptake in PCCL3 thyrocytes

N. Schanze, S. F. Jacobi, E. Rijntjes, S. Mergler, M. Del Olmo, C. S. Hoefig, N. Khajavi, I. Lehmphul, H. Biebermann, J. Mittag and J. Koehrle
Thyroid. 2016 Oct 27 [Epub ahead of print].

3D brown adipogenesis to create Brown-Fat-in-Microstrands

A. M. Unser, B. Mooney, D. T. Corr, Y. H. Tseng and Y. Xie
Biomaterials. 2015 Oct 8. 123-134 [Epub ahead of print].

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

Wenzel C, Riefke B, Grundemann S, Krebs A, Christian S, Prinz F, Osterland M, Golfier S, Rase S, Ansari N, Esner M, Bickle M, Pampaloni F, Mattheyer C, Stelzer E H, Parczyk K, Prechtl S and Steigemann P
Exp Cell Res. 2014 Jan 27 [Epub ahead of print].

3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages

Morrison S and McGee S L
Adipocyte. 2015 Apr 18 [Epub ahead of print].

4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages

Tu T H, Kim C S, Nam-Goong I S, Nam C W, Kim Y I, Goto T, Kawada T, Park T, Yoon Park J H, Ryoo Z Y, Park J W, Choi H S and Yu R
FEBS J. 2015 Feb 18 [Epub ahead of print].

4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes

Lopez-Bernardo E, Anedda A, Sanchez-Perez P, Acosta-Iborra B and Cadenas S
Free Radic Biol Med. 2015 Apr 2 [Epub ahead of print].

5'-AMP-Activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors

Laderoute K R, Calaoagan J M, Chao W R, Dinh D, Denko N, Duellman S, Kalra J, Liu X, Papandreou I, Sambucetti L and Boros L G
J Biol Chem. 2014 Jul 3 [Epub ahead of print].

5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists

J. L. Harmon, L. P. Wills, C. E. McOmish, E. Y. Demireva, J. A. Gingrich, C. C. Beeson and R. G. Schnellmann
J Pharmacol Exp Ther; 2016 Jan 19.

9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes

Kim Y I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N and Kawada T
Mol Nutr Food Res; 2011 Apr 1. 55(4). 585-93

A 3-methylcrotonyl-CoA carboxylase deficient human skin fibroblast transcriptome reveals underlying mitochondrial dysfunction and oxidative stress

L. Zandberg, H. C. van Dyk, F. H. van der Westhuizen and A. A. van Dijk
Int J Biochem Cell Biol. 2016 Jul 12. 116-129 [Epub ahead of print].

A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis

M. Bourens and A. Barrientos
EMBO Rep; 2017 Mar 1. 18(3). 477-494

A Cell-Based Phenotypic Assay to Identify Cardioprotective Agents

Guo S, Olm-Shipman A, Walters A, Urciuoli W R, Devito S, Nadtochiy S M, Wojtovich A P and Brookes P S
Circ Res; 2012 Mar 30. 110(7). 948-57

A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size

Kitami T, Logan D J, Negri J, Hasaka T, Tolliday N J, Carpenter A E, Spiegelman B M and Mootha V K
PLoS One; 2012 Mar 29. 7(3). e33755

A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

A. Bruckbauer, J. Banerjee, L. Fu, F. Li, Q. Cao, X. Cui, R. Wu, H. Shi, B. Xue and M. B. Zemel
Int J Hepatol. 2016 Nov 30 [Epub ahead of print].

A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

A. Bruckbauer, J. Banerjee, L. Fu, F. Li, Q. Cao, X. Cui, R. Wu, H. Shi, B. Xue and M. B. Zemel
Int J Hepatol. 2016 Nov 30 [Epub ahead of print].

A Comparison of Cytotoxicity and Oxidative Stress from Welding Fumes Generated with a New Nickel-, Copper-Based Consumable versus Mild and Stainless Steel-Based Welding in RAW 264.7 Mouse Macrophages

Badding M A, Fix N R, Antonini J M and Leonard S S
PloS one; 2014 Jun 30. 9(6). e101310

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

L. Kazak, E. T. Chouchani, M. P. Jedrychowski, B. K. Erickson, K. Shinoda, P. Cohen, R. Vetrivelan, G. Z. Lu, D. Laznik-Bogoslavski, S. C. Hasenfuss, S. Kajimura, S. P. Gygi and B. M. Spiegelman
Cell. 2015 Oct 22(3). 643-55 [Epub ahead of print].

A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress

J. Ritho, S. T. Arold and E. T. Yeh
Cell Reports. 2015 Jul 23(5). 734-42 [Epub ahead of print].

A Flavonoid Compound Promotes Neuronal Differentiation of Embryonic Stem Cells via PPAR-beta Modulating Mitochondrial Energy Metabolism

Y. Q. Mei, Z. F. Pan, W. T. Chen, M. H. Xu, D. Y. Zhu, Y. P. Yu and Y. J. Lou
PLoS One. 2016 Jun 17(6). e0157747 [Epub ahead of print].

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

J. D. Arroyo, A. A. Jourdain, S. E. Calvo, C. A. Ballarano, J. G. Doench, D. E. Root and V. K. Mootha
Cell Metab. 2016 Sep 9 [Epub ahead of print].

A Gnotobiotic Mouse Model Demonstrates that Dietary Fiber Protects Against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

Donohoe D R, Holley D, Collins L B, Montgomery S A, Whitmore A C, Hillhouse A, Curry K P, Renner S W, Greenwalt A, Ryan E P, Godfrey V, Heise M T, Threadgill D S, Han A, Swenberg J A, Threadgill D W and Bultman S J
Cancer Discov; 2014 Dec 1. 4(12). 1387-97

A H2S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells

Sanokawa-Akakura R, Ostrakhovitch E A, Akakura S, Goodwin S and Tabibzadeh S
PloS One; 2014 Sep 23. 9(9)

A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

Scheibye-Knudsen M, Mitchell Sarah
Cell Metab; 2014 Nov 4. 20(5). 840-855

A Highly Efficient Method for Measuring Oxygen Consumption Rate in Fusarium graminearum

D. Gebhard, J. Bönnighausen, J. Bergemann, W. Schäfer and J. Bormann
Bio-protocol. 2016 Aug 5(15). e1887 [Epub ahead of print].

A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma

S. Rizvi, D. Yamada, P. Hirsova, S. F. Bronk, N. W. Werneburg, A. Krishnan, W. Salim, L. Zhang, E. Trushina, M. J. Truty and G. J. Gores
J Biol Chem. 2016 Jan 29(15). 8031-47 [Epub ahead of print].

A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism

L. Amoasii, W. Holland, E. Sanchez-Ortiz, K. K. Baskin, M. Pearson, S. C. Burgess, B. R. Nelson, R. Bassel-Duby and E. N. Olson
Genes Dev. 2016 Feb 15(4). 434-46 [Epub ahead of print].

A Metabolomics-driven Elucidation of the Anti-obesity Mechanisms of Xanthohumol

Kirkwood J S, Legette L L, Miranda C L, Jiang Y and Stevens J F
J Biol Chem; 2013 Jun 28. 288(26). 19000-19013

A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity

L. R. Gray, A. J. Rauckhorst and E. B. Taylor
J Biol Chem. 2016 Jan 28(14). 7409-17 [Epub ahead of print].

A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia

W. Lv, Z. Zhang, K. Y. Zhang, H. Yang, S. Liu, A. Xu, S. Guo, Q. Zhao and W. Huang
Angew Chem Int Ed Engl; 2016 Jul 6.

A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels

Lanning N J, Looyenga B D, Kauffman A L, Niemi N M, Sudderth J, Deberardinis R J and Mackeigan J P
Cell Rep; 2014 May 8. 7(3). 907-17

A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver

Sood A, Jeyaraju DV, Prudent J, Caron A, Lemieux P, Mcbride HM, Laplante M, Toth K and Pellegrini L
Proc Natl Acad Sci U S A; 2014 Nov 11. 111(45). 16017-22

A Modified Model of T-Cell Differentiation Based on mTOR Activity and Metabolism

Powell J D, Heikamp E B, Pollizzi K N and Waickman A T
Cold Spring Harb Symp Quant Biol. 2013 Oct 7 [Epub ahead of print].

A Novel Method for Pulmonary Research: Assessment of Bioenergetic Function at the Air-liquid Interface

Xu W, Janocha A J, Leahy R A, Klatte R, Dudzinski D, Mavrakis L A, Comhair S A A, Lauer M E, Cotton C U and Erzurum S C
Redox Biology; 2014 Jan 16. 0

A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors

T. Sakata-Kato and D. F. Wirth
ACS Infect Dis. 2016 Oct 9 [Epub ahead of print].

A Novel MitoTimer Reporter Gene for Mitochondrial Content, Structure, Stress, and Damage in Vivo

Laker R C, Xu P, Ryall K A, Sujkowski A, Kenwood B M, Chain K H, Zhang M, Royal M A, Hoehn K L, Driscoll M, Adler P N, Wessells R J, Saucerman J J and Yan Z
J Biol Chem; 2014 Apr 25. 289(17). 12005-12015

A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis

Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH and Goodyear LJ
Diabetes. 2015 Jan 20 [Epub ahead of print].

A PPARgamma-Bnip3 axis couples adipose mitochondrial fusion-fission balance to systemic insulin sensitivity

M. J. Tol, R. Ottenhoff, M. van Eijk, N. Zelcer, J. Aten, S. M. Houten, D. Geerts, C. van Roomen, M. C. Bierlaagh, S. Scheij, M. A. Hoeksema, J. M. Aerts, J. S. Bogan, G. W. Dorn, 2nd, C. A. Argmann and A. J. Verhoeven
Diabetes; 2016 Jun 20.

A Peroxisome Proliferator-activated Receptor {gamma} (PPAR{gamma})/PPAR{gamma} Coactivator 1{beta} Autoregulatory Loop in Adipocyte Mitochondrial Function

Deng T, Sieglaff D H, Zhang A, Lyon C J, Ayers S D, Cvoro A, Gupte A A, Xia X, Baxter J D, Webb P and Hsueh W A
J Biol Chem; 2011 Sep 2. 286(35). 30723-30731

A Phase I Study of the First-in-Class Anti-Mitochondrial Metabolism Agent CPI-613 in Patients with Advanced Hematologic Malignancies

Pardee T S, Lee K, Luddy J, Maturo C, Rodriguez R J, Isom S, Miller L D, Stadelman K M, Levitan D, Hurd D, Ellis L R, Harrelson R, Manuel M, Dralle S, Lyerly S and Powell B L
Clin Cancer Res; 2014 Aug 27.

A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer

R. K. Pathak, R. Wen, N. Kolishetti and S. Dhar
Mol Cancer Ther; 2017 Apr 1. 16(4). 625-636

A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

McQuaker S J, Quinlan C L, Caldwell S T, Brand M D and Hartley R C
Chembiochem; 2013 May 27. 14(8). 993-1000

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

Qiao S, Dennis M, Song X, Vadysirisack D D, Salunke D, Nash Z, Yang Z, Liesa M, Yoshioka J, Matsuzawa S, Shirihai O S, Lee R T, Reed J C and Ellisen L W
Nature Comm; 2015 Apr 29. 6(7014)

A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis

Stark R, Guebre-Egziabher F, Zhao X, Feriod C, Dong J, Alves T C, Ioja S, Pongratz R L, Bhanot S, Roden M, Cline G W, Shulman G I and Kibbey R G
J Biol Chem; 2014 Mar 14. 289(11). 7257-7263

A Role for PGC-1 Coactivators in the Control of Mitochondrial Dynamics during Postnatal Cardiac Growth

Martin O J, Lai L, Soundarapandian M M, Leone T C, Zorzano A, Keller M P, Attie A D, Muoio D M and Kelly D P
Circ Res. 2013 Dec 23 [Epub ahead of print].

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

J. H. Yeo, J. P. Skinner, M. J. Bird, L. E. Formosa, J. G. Zhang, R. M. Kluck, G. T. Belz and M. M. Chong
PLoS One. 2015 Jul 30(7). e0134326 [Epub ahead of print].

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

Schell John
Mol Cell; 2014 Oct 30. 56(3). 400-413

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays

Chan G K, Kleinheinz T L, Peterson D and Moffat J G
PloS one; 2013 May 22. 8(5). e63583

A Simple Method for Labeling Human Embryonic Stem Cells Destined to Lose Undifferentiated Potency

A. Kumagai, M. Suga, K. Yanagihara, Y. Itoh, H. Takemori and M. K. Furue
Stem Cells Transl Med. 2016 Mar 1(3). 275-81 [Epub ahead of print].

A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth Through HIF-1/2alpha

Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY and Miller BA
J Biol Chem; 2014 Dec 26. 289(52). 36284-302

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to beta-Cell Mitochondrial Dysfunction in Type 2 Diabetes

H. Peiris, M. D. Duffield, J. Fadista, C. F. Jessup, V. Kashmir, A. J. Genders, S. L. McGee, A. M. Martin, M. Saiedi, N. Morton, R. Carter, M. A. Cousin, A. C. Kokotos, N. Oskolkov, P. Volkov, T. A. Hough, E. M. Fisher, V. L. Tybulewicz, J. Busciglio, P. E. Coskun, A. Becker, P. V. Belichenko, W. C. Mobley, M. T. Ryan, J. Y. Chan, D. R. Laybutt, P. T. Coates, S. Yang, C. Ling, L. Groop, M. A. Pritchard and D. J. Keating
PLoS Genet. 2016 May 19(5). e1006033 [Epub ahead of print].

A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure

Sridharan V, Tripathi P, Aykin-Burns N, Krager K J, Sharma S K, Moros E G, Melnyk S B, Pavliv O, Hauer-Jensen M and Boerma M
Radiat Res; 2015 Mar 1. 183(3). 357-66

A bioassay to measure energy metabolism in mouse colonic crypts, organoids and sorted stem cells

Fan Y Y, Davidson L A, Callaway E S, Wright G A, Safe S and Chapkin R S
AJP-GI; 2015 May 14. ajpgi 00052 02015. 2015

A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity

Nickens K P, Wikstrom J D, Shirihai O S, Patierno S R and Ceryak S
Mitochondrion; 2013 Sep 27. 13(6). 662-667

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, Umezawa A, Greer PA and Urano F
Proc Natl Acad Sci U S A; 2014 Dec 9. 111(49). E5292-301

A combined in vitro approach to improve the prediction of mitochondrial toxicants

J. Eakins, C. Bauch, H. Woodhouse, B. Park, S. Bevan, C. Dilworth and P. Walker
Toxicol In Vitro. 2016 Apr 12. 161-170 [Epub ahead of print].

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

Koeck T, Olsson A H, Nitert M D, Sharoyko V V, Ladenvall C, Kotova O, Reiling E, Ronn T, Parikh H, Taneera J, Eriksson J G, Metodiev M D, Larsson N G, Balhuizen A, Luthman H, Stancakova A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Muld
Cell Metab; 2011 Jan 5. 13(1). 80-91

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis

Baughman J M, Nilsson R, Gohil V M, Arlow D H, Gauhar Z and Mootha V K
PLoS Genet; 2009 Aug 1. 5(8). e1000590

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

Yizhak K, Le Devedec S E, Rogkoti V M, Baenke F, de Boer V C, Frezza C, Schulze A, van de Water B and Ruppin E
Mol Syst Biol. 2014 Aug 1(8). 744 [Epub ahead of print].

A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells

W. Mughal, L. Nguyen, S. Pustylnik, S. C. da Silva Rosa, S. Piotrowski, D. Chapman, M. Du, N. S. Alli, J. Grigull, A. J. Halayko, M. Aliani, M. K. Topham, R. M. Epand, G. M. Hatch, T. J. Pereira, S. Kereliuk, J. C. McDermott, C. Rampitsch, V. W. Dolinsky and J. W. Gordon
Cell Death Dis. 2015 Oct 29. e1944 [Epub ahead of print].

A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast

F. Collard, F. Baldin, I. Gerin, J. Bolsee, G. Noel, J. Graff, M. Veiga-da-Cunha, V. Stroobant, D. Vertommen, A. Houddane, M. H. Rider, C. L. Linster, E. Van Schaftingen and G. T. Bommer
Nat Chem Biol; 2016 Jun 13.

A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells

Shen J, Liu X, Yu W M, Liu J, Groot Nibbelink M, Guo C, Finkel T and Qu C K
Mol Cell Biol; 2011 Dec 1. 31(24). 4902-4916

A cytotoxic Petiveria alliacea dry extract induces ATP depletion and decreases β-F1-ATPase expression in breast cancer cells and promotes survival in tumor-bearing mice

J. F. Hern�ndez, C. P. Urue�a, T. A. Sandoval, M. C. Cifuentes, L. Formentini, J. M. Cuezva and S. Fiorentino
Revista Brasileira de Farmacognosia. 2017 Feb 9 [Epub ahead of print].

A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function

M. Wang, Y. Peng, J. Zheng, B. Zheng, X. Jin, H. Liu, Y. Wang, X. Tang, T. Huang, P. Jiang and M. X. Guan
Nucleic Acids Res; 2016 Aug 17.

A deafness-associated tRNAHis mutation alters the mitochondrial function, ROS production and membrane potential

Gong S, Peng Y, Jiang P, Wang M, Fan M, Wang X, Zhou H, Li H, Yan Q, Huang T and Guan M X
Nucleic Acids Res; 2014 Aug 1. 42(12). 8039-48

A dual role for autophagy in a murine model of lung cancer

Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, Sykacek P, Frank L, Schramek D, Komnenovic V, Sigl V, Aumayr K, Schmauss G, Fellner N, Handschuh S, Glosmann M, Pasierbek P, Schlederer M, Resch G P, Ma Y, Yang H, Popper H, Kenner L, Kro
Nat Commun; 2014 Jan 20. 5(3056)

A family with paroxysmal nonkinesigenic dyskinesias (PNKD): Evidence of mitochondrial dysfunction

Ghezzi D, Canavese C, Kovacevic G, Zamurovic D, Barzaghi C, Giorgi C, Zorzi G, Zeviani M, Pinton P, Garavaglia B and Nardocci N
European Journal of Paediatric Neurology. 2014 Oct 17 [Epub ahead of print].

A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells

Segales J, Paz J C, Hernandez-Alvarez M I, Sala D, Munoz J P, Noguera E, Pich S, Palacin M, Enriquez J A and Zorzano A
Am J Physiol Endocrinol Metab.; 2013 Nov 1. 305(10). E1208-1221

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: A role for Monocarboxylate Transporters as metabolic targets for therapy

Pertega-Gomes N, Felisbino S, Massie C E, Vizcaino J R, Coelho R, Sandi C, Sousa S, Jurmeister S, Ramos-Montoya A, Asim M, Tran M, Oliveira E, Lobo da Cunha A, Maximo V, Baltazar F, Neal D E and Fryer L G
The Journal of pathology. 2015 Apr 15 [Epub ahead of print].

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

Beeson C C, Beeson G C and Schnellmann R G
Anal Biochem; 2010 Sep 1. 404(1). 75-81

A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents

S. Datta, S. Sahdeo, J. A. Gray, C. Morriseau, B. D. Hammock and G. Cortopassi
Mitochondrion; 2016 Nov 1. 31. 79-83

A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome

I. A. Chatzispyrou, M. Alders, S. Guerrero-Castillo, R. Zapata Perez, M. A. Haagmans, L. Mouchiroud, J. Koster, R. Ofman, F. Baas, H. R. Waterham, J. N. Spelbrink, J. Auwerx, M. M. Mannens, R. H. Houtkooper and A. S. Plomp
Hum Mol Genet. 2017 Apr 25 [Epub ahead of print].

A hypertension-associated tRNAAla mutation alters the tRNA metabolism and mitochondrial function

P. Jiang, M. Wang, L. Xue, Y. Xiao, J. Yu, H. Wang, J. Yao, H. Liu, Y. Peng, H. Liu, H. Li, Y. Chen and M. X. Guan
Mol Cell Biol; 2016 May 9.

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov V A, Mackay G, van der Burg S H, Verdegaal E M, Cascante M, Shlomi T, Gottlieb E and Peeper D S
Nature; 2013 May 19. 498(7452). 109-12

A metabolic phenotype based on mitochondrial ribosomal protein expression as a predictor of lymph node metastasis in papillary thyroid carcinoma

Lee J, Seol MY, Jeong S, Lee CR, Ku CR, Kang SW, Jeong JJ, Shin DY, Nam KH, Lee EJ, Chung WY and Jo YS
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AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

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ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21

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AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

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ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate

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ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD(+) Depletion

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ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway

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ATP citrate lyase improves mitochondrial function in skeletal muscle

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ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

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AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation

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Ablation of Dihydroceramide Desaturase-1, a Therapeutic Target for the Treatment of Metabolic Diseases, Simultaneously Stimulates Anabolic and Catabolic Signaling

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Mitochondrial and Morphologic Alterations in Native Human Corneal Endothelial Cells Associated With Diabetes Mellitus

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Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis

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