Ets-related gene (ERG) product is a ~41 kDa nuclear protein functioning as a DNA-binding transcriptional regulator that belongs to the erythroblast transformation-specific (ETS) family of transcription factors. In prostate cancer, ERG has most frequently been shown as a fusion protein with transmembrane protease, serine 2 (TMPRSS2), where a deletion between the TMPRSS2
genes causes the ERG
gene to come under the control of the androgen-responsive promoter elements of TMPRSS2
This antibody is a useful aid for the classification of prostate adenocarcinoma (1, 2). Furthermore, ERG may also be a useful aid for classification of prostatic intraepithelial neoplasia (PIN) and vascular tumors.