Skip to main content

Charge Variant Analysis

Robust Analysis of Protein Charge Variants

Charge heterogeneity of proteins can change during the biopharmaceutical production and purification process. These changes can potentially impact stability, activity of the drug, and in some cases cause adverse immunological reactions. The identification and monitoring of charge variants are important throughout the biomanufacturing process.

Agilent has developed robust solutions that streamline your method development process. You can identify and monitor charge variants with the use of Agilent’s microfluidic and electrophoresis platforms, a large selection of ion exchange columns and a totally bio-inert chromatography UHPLC system.