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Includes 6495B brochure, technical and application notes

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Get the day-to-day reliability and analytical sensitivity that your workflow demands

When samples are limited and turnaround time is short, a sensitive, yet rugged analytical instrument is critical to your success. The Agilent 6495B Triple Quadrupole LC/MS system is at the forefront of robustness, reliability, and accuracy—making it the perfect option for applications such as peptide quantitation, food safety, environmental, clinical research, and forensics.

Targeted Proteomics: Peptide identification and selection

Extended mass range triple quadrupole LC/MS enables routine analysis of high mass-to-charge peptide ions

High m/z peptide ions provide important biological information concerning the size and location of post-translation modifications. The mass range of the Agilent 6495B Triple Quadrupole LC/MS system extends to m/z 3000, which is ideal for detecting large peptide fragments.

In this application, we used the 6495B to detect fragment-ion signals arising from peptides representing each of the targeted proteins. This approach is extremely sensitive, very reproducible, and quantitatively precise.

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For Research Use Only. Not for use in diagnostic procedures.

Food Testing—Pesticides: Evaluation of optimized inter-MRM delay times

Fast data acquisition speed and high quantitative performance:
Simultaneous determination of mycotoxins, illegal dyes, and pesticides in spices

Reports of contamination by illegal pesticides and adulterants have prompted increased scrutiny of food safety and origin. Triple quadrupole LC/MS can help you meet this challenge by simultaneously monitoring hundreds of potential contaminants.

In this application, we developed an analytical MRM method targeting mycotoxins, illegal dyes, and pesticides in spices. The highly sensitive Agilent 6495B Triple Quadrupole LC/MS system enabled precise, accurate quantitation of these excipients—with reduced matrix effects and improved method robustness.

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Environmental Water Analysis: Accuracy and precision for measuring PPCPs in water

Sensitive, high-throughput triple quadrupole UHPLC determination of PPCPs in water using optimized MS cycle times

From heroin and cardamom… to rocket fuel and birth control active ingredients… scientists worldwide are encountering trace amounts of pharmaceuticals and personal care products (PPCPs) in the water we drink. Often, these compounds are not completely removed during sewage treatment, allowing drug-tainted wastewater to contaminate major sources of drinking water.

The high accuracy, precision, and analytical sensitivity of the Agilent 6495B Triple Quadrupole LC/MS system enables direct injection of water samples with prior sample pre-concentration. In this example, we performed screening and quantitative analyses of 32 PPCPs in surface water samples at levels as low as 0.5 ng/L (ppb).

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Jet Stream technology promotes efficient desolvation and creates an ion-rich zone

Hexabore capillary: Six capillary inlets sample 10 times more ion-rich gas

Dual ion funnel removes the gas, but captures the ions

Enhanced Q1 ion optics improve ion transmission

Curved, tapered hexapole collision cell effectively collects and transmits ions

Detector: High-energy conversion dynode reduces noise and improves negative ion detection

Streamline your analytical workflow with increased sensitivity and precision

Building on the legendary reliability of Agilent systems, the 6495B Triple Quadrupole LC/MS system incorporates hardware and software innovations that deliver high-quality analytical performance and robust, repeatable results.

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Roll your mouse over the highlighted areas to explore the productivity-boosting features of this advanced LC/MS system.

MassHunter Software More data…more possibilities

Every generation of triple quadrupole LC/MS instruments provides enhanced capabilities—particularly in the area of analytical sensitivity. That means the breadth and depth of your data is increasing exponentially, which is good news for your lab.

Now, here’s even better news: Agilent MassHunter software makes triple quadrupole LC/MS even more powerful by giving you new ways to turn data into insights. Click on the videos below for an up-close look at this integrated, intuitive software.

Triggered MRM and Library Matching


Data Review: Batch at-a-glance and outliers


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