PALO ALTO, Calif., Nov. 6, 2003
Varian, Inc. today introduced a new HPLC column for its Helix(TM) System, a fully automated tool for DNA mutation detection and SNP discovery based on the technique of DHPLC (Denaturing High Performance Liquid Chromatography).
Varian, Inc.'s new column uses patent-pending monolithic polymer technology to reduce scientists' per analysis costs by increasing column lifetimes. The column is also compatible with emerging applications in high temperature RNA separations. The new Helix column uses 50 percent less solvent than competing columns, and cuts buffer costs in half.
DHPLC has proven to be an important tool for biomolecular scientists involved in fundamental DNA research and in (genetics). By studying variations in the DNA sequence scientists have made significant advances in their understanding of the genetic basis of such diseases as breast cancer and colon cancer. Researchers use Varian's Helix System to determine if an individual possesses a specific DNA mutation of known significance or to find previously unknown mutations. This information provides researchers with valuable information about an individual's inherited risk of a disorder.
The Varian Helix System has played an important role in sample processing for the Colon Cancer Family Registry Consortium, a National Cancer Institute-funded international consortium dedicated to building a resource available for research into colorectal cancer.
Melissa Barker, member of the NIH funded CFR Consortium and the Queensland Institute of Medical Research notes, "We have used the Varian Helix DHPLC System for almost three years now and have processed hundreds of samples for a variety of genes associated with colorectal cancer. Varian's new Helix Column has performed well in our testing and evaluation, and has proved integral in helping us establish the quality control standard for mutation detection across the CFR. We expect it to significantly cut our per sample costs."
Varian, Inc.'s Helix System is specifically designed as a complete packaged solution for bio-molecular applications including small-scale genotyping, DNA sizing, and oligonucleotide purification. It is based on a DHPLC platform, includes unique classification software, and the most precise temperature control available for DNA analysis.
Varian, Inc.'s new Helix column can be purchased separately, or can be sold with a new Helix System, and is available immediately for order and delivery.
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About Varian, Inc.
Varian, Inc. is a major supplier of scientific instruments, vacuum technologies, and specialized contract electronics manufacturing services. These businesses serve a broad range of life science and industrial customers worldwide. The company manufactures in 15 locations in North America, Europe, and the Pacific Rim and employs some 4,300 people. Varian, Inc. had fiscal year 2003 sales of $848 million. Additional information about Varian is available at www.varianinc.com.
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Lauren Lum of Varian, Inc.