Agilent celebrates 50 years in analytical

Agilent celebrates 50 years in analytical

On August 9, 1965, the Hewlett-Packard Co. finalized its fifth acquisition, a company in Avondale, Pennsylvania, called F&M Scientific.  At the time, F&M Scientific was one of the world's leading manufacturers of a new technology called gas chromatography.

One of the world's first gas chromatographs: The F&M 17AOne of the world's first gas chromatographs: the F&M 17A

F&M Scientific began as a part-time basement operation run by an employee of U.S chemical giant DuPont.  Frank Martinez Jr. was a glassblower who worked on analytical and process instruments for in-house use.  In 1956, he obtained permission to manufacture gas chromatographs in his spare time.  The company took off after a successful advertisement in the magazine Analytic Chemistry, and Martinez resigned from DuPont in 1958 to run F&M (named after his initials) full-time.

When two other former DuPont scientists – Aaron Martin and C. Eugene Bennett – offered to buy F&M, Martinez proposed a partnership instead.  All three founders would later be inducted into the Chemical Heritage Foundation's "Instrumentation Hall of Fame."

F&M 202 gas chromatograph (195X) F&M 202 gas chromatograph (195X)

F&M wanted to exhibit at the 1959 Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (also known as "Pittcon"), but was unable to secure a booth.  Instead, the team set up in a room on the second floor of the hotel.  They displayed the first programmable high-temperature chromatograph, which used a thermal-conductivity detector and could operate at temperatures up to 300°C.  The instrument became the star of the show, attracting customers including Pfizer, Dow and Esso.  For the first time, materials such as petroleum, polymers and drugs could be analyzed in a matter of minutes.

Within a year, F&M extended its temperature range to 500°C.  The company grew from three employees to 25, hiring most of the graduating class of Wilmington's Brown Vocational Technical High School as manufacturing staff.  Sales doubled from $250,000 to $500,000, and continued to double every year.  Within three years, F&M Scientific had become the world's largest producer of gas chromatographic equipment.

And in 1965, with 400 employees and $7 million in annual sales, the company was sold to Hewlett-Packard.

HP continued to operate F&M as a separate business, now called the F&M Scientific Division, and expanded into new markets including environmental, food and drug testing, and crime detection.

From left: Aaron Martin, E. Eugene Bennett and Frank Martinez, Jr. From left: Aaron Martin, C. Eugene Bennett and Frank Martinez Jr.

"F&M's gas chromatographs, which can accurately identify and measure minutely small traces of material, are installed in numerous laboratories engaged in pollution control and research," said a 1967 HP employee newsletter.  Applications included analysis of automotive exhaust, air pollution, pesticides, water quality and pollution.

HP also signed a contract with the federal government to develop a specialized line of portable laboratories for testing food products, including grains, forage, dairy and fruits."Agricultural inspectors will be able to walk right out into the middle of an alfalfa field, take a sample, run it through the portable, self-powered F&M gas chromatograph, and perform all other necessary tests on the spot," the company proclaimed.

HP F&M laboratory chromatograph (196X)HP F&M laboratory chromatograph (196X)

 

In 1967, German biochemist Manfred Donike demonstrated that an HP gas chromatograph could be used to detect anabolic steroids and other prohibited substances in athletes' urine samples.  As a result, full-scale testing of athletes was conducted for the first time at the 1972 Summer Olympics in Munich, using eight HP gas chromatographs.

Manfred Donike using a 7600A HP gas chromatograph at the 1972 Olympic Games in Munich Manfred Donike using a 7600A HP gas chromatograph at the 1972 Olympic Games in Munich
Clockwise from upper left: The HP 5390A mas spectrometer (1971), the Hupe & Busch 1010B liquid chromatograph (1973), the HP 5890 GC (1984), fused silica capillary columns (1979)Clockwise from upper left: The HP 5390A mass spectrometer (1971), the Hupe & Busch 1010B liquid chromatograph (1973), the HP 5890 GC (1984), fused silica capillary columns (1979)

HP continued its growth in analytical instrumentation. In 1970 it created the Scientific Instruments Division to develop new technologies for mass spectrometry. In 1973 it entered another adjacent market, liquid chromatography, through the acquisition of Hupe & Busch. One of the company's most innovative technology breakthroughs was the 1979 invention of fused silica capillary columns, which simplified chemical analysis and enabled more compounds to be analyzed. And the HP 5890, introduced in 1984, remains the best-selling gas chromatograph instrument of all time.

 

The rebirth of chemical analysis

The spinoff of Agilent in 1999 included life sciences and chemical analysis. But while life sciences was seen as a growth engine and investment area for the company, chemical analysis was regarded as an older, slow-growth business whose best days were behind it.

November 18, 1999: Agilent celebrates its IPO by ringing the opening bell at the New York Stock Exchange November 18, 1999: Agilent celebrates its initial public offering by ringing the opening bell at the New York Stock Exchange

Mike McMullen, who led chemical analysis at the time, realized that while the chemical market in the U.S. was slowing, China, other emerging economies and the global food market were getting ready to explode. In fact, emerging economies throughout the world needed to improve the quality of their food, air, water and environments. The business shifted the bulk of its investment dollars from the U.S. and Europe into China, India and other emerging economies.

Over the next several years, chemical analysis became one of Agilent's highest-growth and highest-profit businesses. McMullen's success in leading chemical analysis helped him to be named Agilent's third president and CEO.

A brief history of HP/Agilent's revenue growth and technology milestones in life sciences, diagnostics and applied chemical marketsA brief history of HP/Agilent's revenue growth and technology milestones in life sciences, diagnostics and applied chemical markets

 

Fifty years after the acquisition of F&M Scientific, Agilent’s future looks bright. Leadership in chemical analysis has enabled the company to invest in life sciences, genomics and diagnostics. Last year, Agilent reintroduced itself as a $4 billion company completely focused on those industries.

"We are building a company that will bridge our expertise in analytics to new worlds in the growing life sciences and diagnostics fields," McMullen told employees at a recent anniversary celebration. "We are creating a better world. We are changing people’s lives. What could be better than coming to work every day to make that kind of change in the world?"


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